Copper metal-organic polyhedra nanorods with high intrinsic peroxidase-like activity at physiological pH for bio-sensing
Copper metal-organic polyhedra nanorods with high intrinsic peroxidase-like activity at physiological pH for bio-sensing
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DOI：
10.1039/c7tb02388j
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发表时间：
2017-12-21
影响因子：
7
通讯作者：
Ding, Zhongtao
中科院分区：
文献类型：
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作者：
Qin, Yu;Zhang, Qin;Ding, Zhongtao
模拟酶的纳米材料（纳米酶）已被用于催化酶样反应的各种应用。尽管有这些有利的特性，但模拟过氧化物酶的纳米酶在酸性溶液中发生最佳反应，这极大地限制了它们在生物系统中的应用。在此，我们证明了铜金属有机多面体（Cu-MOP）纳米棒在生理pH值下表现出高的过氧化物酶模拟活性。Cu-MOP纳米棒在鲁米诺/H2O2存在下催化产生强化学发光信号，在中性pH溶液中，H2O2氧化2,2'-氮化萘-（3-乙基苯并噻唑-6-磺酸）（ABTS）产生绿色反应。将Cu-MOP纳米棒驱动的显色反应应用于H2O2传感器的开发，并进一步实现了葡萄糖检测平台的开发。
Enzyme-mimicking nanomaterials (nanozymes) have been used to catalyze enzyme-like reactions for various applications. Despite these favorable properties, peroxidase-mimicking nanozymes suffer from the optimum reaction occurring in acidic solutions, which greatly limits their applications in biological systems. Herein, we demonstrate that copper Metal-Organic Polyhedra (Cu-MOP) nanorods exhibit high peroxidase-mimicking activity at a physiological pH value. Cu-MOP nanorods catalyze the generation of strong chemiluminescence signals in the presence of luminol/H2O2 and the oxidation of 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulphonate acid) (ABTS) by H2O2 produces a green color reaction in a neutral pH solution. The Cu-MOP nanorod driven generation of color reactions is applied to develop a H2O2 sensor, and furthermore is implemented to develop a glucose detection platform.