Systemic and cerebral oxygen extraction after human cardiac arrest
Systemic and cerebral oxygen extraction after human cardiac arrest
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DOI：
10.1097/00063110-199603000-00004
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发表时间：
1996-03
影响因子：
4.4
通讯作者：
M. Müllner;F. Sterz;H. Domanovits;A. Zeiner;A. Laggner
中科院分区：
文献类型：
--
作者：
M. Müllner;F. Sterz;H. Domanovits;A. Zeiner;A. Laggner
本研究的目的是观察人类心脏骤停后自主循环恢复后的脑部和全身氧提取情况。包括八名非创伤性心脏骤停后的成年患者。从心脏骤停后 2 小时开始测量脑和全身氧提取率以及血流动力学变量，此后每 4 小时测量一次，直至 24 小时。心脏骤停后 2 至 12 小时之间，脑氧提取值范围从非常低、正常到非常高。在进一步的治疗过程中，6 名患者的这些值一直下降到 24 小时。两名 6 个月后仍然活着的患者（均为严重精神障碍）与非幸存者相比，脑氧摄取率更高。全身吸氧量似乎比脑吸氧量变化更大。两名长期幸存者在 8 至 24 小时内的数值均处于正常至超常水平。总之，在事件发生后 12 至 24 小时内，长期心脏骤停幸存者的脑氧摄取量高于非幸存者。此外，更好的神经恢复质量与更高的脑氧摄取量相关。全身吸氧量也受到损害，但程度较轻，尤其是长期幸存者。
The aim of this study was to observe cerebral and systemic oxygen extraction after human cardiac arrest with return of spontaneous circulation. Eight adult patients after non-traumatic, cardiac arrest were included. Cerebral and systemic oxygen extraction ratios were measured together with haemodynamic variables beginning 2 hours after cardiac arrest and every 4 hours thereafter until 24 hours. Between 2 and 12 hours after cardiac arrest cerebral oxygen extraction values ranged from very low over normal to very high. In the further course these values were reduced until 24 hours in six patients. Two patients who were still alive after 6 months, both severely mentally disabled, had a higher cerebral oxygen extraction ratios in comparison with non-survivors. Systemic oxygen extraction seemed to vary more than the cerebral oxygen extraction. The two long-term survivors had normal to supranormal values from 8 to 24 hours. In conclusion cerebral oxygen extraction was higher in long-term cardiac arrest survivors than in non-survivors between 12 and 24 hours after the event. Further, a better quality of neurological recovery was associated with higher cerebral oxygen extraction. Systemic oxygen extraction was also impaired, but to a lesser extent, especially in long-term survivors.