Carbonylative Coupling of Alkyl Zinc Reagents with Benzyl Bromides Catalyzed by a Nickel/NN2Pincer Ligand Complex
Carbonylative Coupling of Alkyl Zinc Reagents with Benzyl Bromides Catalyzed by a Nickel/NN2Pincer Ligand Complex
复制标题
DOI：
10.1002/anie.201710089
复制
发表时间：
2018-01-15
影响因子：
16.6
通讯作者：
Skrydstrup, Troels
中科院分区：
文献类型：
--
作者：
Andersen, Thomas L.;Donslund, Aske S.;Skrydstrup, Troels
An efficient catalytic protocol for the three-component assembly of benzyl bromides, carbon monoxide, and alkyl zinc reagents to give benzyl alkyl ketones is described, and represents the first nickel-catalyzed carbonylative coupling of two sp(3)-carbon fragments. The method, which relies on the application of nickel complexed with an NN2-type pincer ligand and a controlled release of CO gas from a solid precursor, works well with a range of benzylic bromides. Mechanistic studies suggest the intermediacy of carbon-centered radicals.
