Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses.
Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses.
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DOI：
10.1038/s41586-021-03594-0
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发表时间：
2021-06
期刊：
影响因子：
64.8
通讯作者：
Haynes BF
中科院分区：
文献类型：
--
作者：
Saunders KO;Lee E;Parks R;Martinez DR;Li D;Chen H;Edwards RJ;Gobeil S;Barr M;Mansouri K;Alam SM;Sutherland LL;Cai F;Sanzone AM;Berry M;Manne K;Bock KW;Minai M;Nagata BM;Kapingidza AB;Azoitei M;Tse LV;Scobey TD;Spreng RL;Rountree RW;DeMarco CT;Denny TN;Woods CW;Petzold EW;Tang J;Oguin TH 3rd;Sempowski GD;Gagne M;Douek DC;Tomai MA;Fox CB;Seder R;Wiehe K;Weissman D;Pardi N;Golding H;Khurana S;Acharya P;Andersen H;Lewis MG;Moore IN;Montefiori DC;Baric RS;Haynes BF
Betacoronaviruses (betaCoVs) caused the severe acute respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS) outbreaks, and the SARS-CoV-2 pandemic. Vaccines that elicit protective immunity against SARS-CoV-2 and betaCoVs circulating in animals have the potential to prevent future betaCoV pandemics. Here, we show that macaque immunization with a multimeric SARS-CoV-2 receptor binding domain (RBD) nanoparticle adjuvanted with 3M-052/Alum elicited cross-neutralizing antibody (cross-nAb) responses against batCoVs, SARS-CoV-1, SARS-CoV-2, and SARS-CoV-2 variants B.1.1.7, P.1, and B.1.351. Nanoparticle vaccination resulted in a SARS-CoV-2 reciprocal geometric mean neutralization ID50 titer of 47,216, and protection against SARS-CoV-2 in macaque upper and lower respiratory tracts. Importantly, nucleoside-modified mRNA encoding a stabilized transmembrane spike or monomeric RBD also induced SARS-CoV-1 and batCoV cross-nAbs, albeit at lower titers. These results demonstrate current mRNA vaccines may provide some protection from future zoonotic betaCoV outbreaks, and provide a platform for further development of pan-betaCoV vaccines.
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影响因子：
64.5
作者：
Hou, Yixuan J.;Okuda, Kenichi;Baric, Ralph S.
通讯作者：
Baric, Ralph S.
影响因子：
10.8
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McLellan, Jason S.
影响因子：
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通讯作者：
Wilson, Ian A
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通讯作者：
Plummer, F