Evaluation of outcome and QOL in patients with craniofacial resection for malignant tumors involving the anterior skull base
Evaluation of outcome and QOL in patients with craniofacial resection for malignant tumors involving the anterior skull base
复制标题
累及前颅底恶性肿瘤颅面切除术患者的预后和生活质量评价
作者：
K. Fukuda;N. Saeki;S. Mine;Masaru Oga;A. Yamaura;J. Yuza;H. Nagata;T. Numata;Yoshiaki Konno
摘要本研究的目的是回顾性评价前颅面切除术治疗累及前颅底的鼻腔鼻旁恶性肿瘤的疗效。在1992至1998年间，13例鼻腔或副鼻腔恶性肿瘤患者接受了这种手术。对转移或复发的部位、时间和生存结局进行回顾性调查。通过问卷调查，对长期存活患者的现状及对手术治疗的主观评价进行评估。中位随访期52个月。9名患者(69%)活着，没有疾病的证据。在这些患者中，有8人存活了三年以上。复发或转移4例(31%)。手术至复发或转移的平均时间为11个月。根据对长期存活患者的问卷调查结果，89%的患者有一些抱怨。特别是，所有这些患者都抱怨外观难看。当患者自己评估手术治疗后的现状时，63%的患者表示不满意。这些结果表明，就生存结果而言，这种手术治疗对于选定的患者是有效的。然而，当评估这种治疗的有效性时，心理和功能问题不应掉以轻心。[Neurol res 2000；22：545-550]
Abstract The purpose of this study was to retrospectively evaluate the effectiveness of anterior craniofacial resection in the treatment of nasal and paranasal malignant tumors involving anterior skull base. Between 1992 and 1998, 13 patients with nasal or paranasal malignant tumors underwent this surgical procedure. The site and time of metastasis or recurrence, and survival outcome were retrospectively surveyed. Current status of long-surviving patients and their subjective assessment of the surgical treatment were also evaluated through questionnaires. Median follow-up period was 52 months. Nine patients (69%) were alive with no evidence of disease. Of these patients, eight had survived for more than three years. Recurrence or metastasis occurred in four patients (31%). The mean time interval between surgery and recurrence or metastasis was 11 months. According to the results of questionnaires to long-surviving patients, 89% patients had some complaints. In particular, complaints of unsightly appearance were manifested by all these patients. When the patients themselves evaluated their current conditions resulting from this surgical treatment, 63% were dissatisfied. These results suggest that this surgical treatment is valid for selected patients in regard to survival outcome. When the effectiveness of this treatment is evaluated, however, psychological and functional issues should not be taken lightly. [Neurol Res 2000; 22: 545-550]