Regulation of Virus Replication and T Cell Homeostasis by N~6- Methyladenosine
Regulation of Virus Replication and T Cell Homeostasis by N~6- Methyladenosine
复制标题
N~6-甲基腺苷对病毒复制和T细胞稳态的调节
DOI：
10.1007/s12250-018-0075-5
复制
发表时间：
2019
影响因子：
5.5
通讯作者：
Zhang Wenyan
中科院分区：
文献类型：
--
作者：
Yang Jing;Wang Hong;Zhang Wenyan
RNA的修饰在真核生物，细菌和古细菌中很丰富。 ASERS'和特定的M6A结合蛋白（YTHDF1-3）作为``读者''。 Further, it is important for the regulation of cell fate and has a critical function in many biologic processes including virus replication, stem cell differentiation, and cancer development, and exerts its effect by controlling gene expression. Herein, we summarize recent advances in research on m~6A in virus replication and T cell regulation, which is a rapidly emerging field that will support the development of antiviral therapies and the study of innate immunosunity.
RNA modifications are abundant in eukaryotes, bacteria, and archaea. N~6-methyladenosine (m~6A), a type of RNA modification mainly found in messenger RNA (mRNA), has significant effects on the metabolism and function of mRNAs. This modification is governed by three types of proteins, namely methyltransferases as ‘‘writers'', demethylases as ‘‘erasers'', and specific m6A-binding proteins (YTHDF1-3) as ‘‘readers''. Further, it is important for the regulation of cell fate and has a critical function in many biological processes including virus replication, stem cell differentiation, and cancer development, and exerts its effect by controlling gene expression. Herein, we summarize recent advances in research on m~6A in virus replication and T cell regulation, which is a rapidly emerging field that will facilitate the development of antiviral therapies and the study of innate immunity.