Timing of target discrimination in human frontal eye fields
Timing of target discrimination in human frontal eye fields
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DOI：
10.1162/0898929041502634
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发表时间：
2004-07-01
影响因子：
3.2
通讯作者：
Walsh, V
中科院分区：
文献类型：
--
作者：
O'Shea, J;Muggleton, NG;Walsh, V
额眼区（FEF）神经元响应与行为相关的刺激而放电，这些刺激是扫视的潜在目标。猕猴FEF中已分离出不同的视觉和运动过程，但对人类FEF的视觉处理能力知之甚少。我们采用双脉冲经颅磁刺激[(d)TMS]来研究视觉连接搜索中目标识别的时间。我们在右FEF和顶点上施加了两个间隔40毫秒的TMS脉冲。这些方法在五种时间条件下应用于视觉处理的前200毫秒内的单独时间窗。(d)经颅磁刺激损害了搜索性能，反映在d'分数下降上。这种影响被限制在搜索阵列开始后40到80毫秒的时间窗口内。这些参数与FEF中的单细胞活动相对应，FEF预测猴子在命中、未命中、误报和正确拒绝试验中的行为报告。我们的研究结果表明，人类FEF在视觉目标识别中的早期作用是独立于扫视编程的。
Frontal eye field (FEF) neurons discharge in response to behaviorally relevant stimuli that are potential targets for saccades. Distinct visual and motor processes have been dissociated in the FEF of macaque monkeys, but little is known about the visual processing capacity of FEF in humans. We used double-pulse transcranial magnetic stimulation [(d)TMS] to investigate the timing of target discrimination during visual conjunction search. We applied dual TMS pulses separated by 40 msec over the right FEF and vertex. These were applied in five timing conditions to sample separate time windows within the first 200 msec of visual processing. (d)TMS impaired search performance, reflected in reduced d' scores. This effect was limited to a time window between 40 and 80 msec after search array onset. These parameters correspond with single-cell activity in FEF that predicts monkeys' behavioral reports on hit, miss, false alarm, and correct rejection trials. Our findings demonstrate a crucial early role for human FEF in visual target discrimination that is independent of saccade programming.