Post-prandial decrease of circulating human ghrelin levels
Post-prandial decrease of circulating human ghrelin levels
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DOI：
10.1007/bf03351037
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发表时间：
2001-06-01
影响因子：
5.4
通讯作者：
Folwaczny, C
中科院分区：
文献类型：
--
作者：
Tschöp, M;Wawarta, R;Folwaczny, C
胃饥饿素是生长激素促分泌素受体的一种内源性配体，最近研究表明它在啮齿动物中可刺激生长激素分泌，并具有促进食欲和脂肪生成的作用，但对其在人类中的调节和生物学功能知之甚少。胃运动功能受中枢神经系统控制；然而，这种反馈控制机制的传入和传出回路仍有待阐明。在此项研究中，我们研究了营养摄入对人循环胃饥饿素水平的影响，以及胃饥饿素水平与胃排空之间可能存在的关联。10名健康志愿者在禁食过夜后接受了一顿标准餐。进食后血浆胃饥饿素水平从248.5±15.0显著下降至179.5±17.9飞摩尔/毫升（餐后120分钟，p = 0.047）。胃排空半衰期（无创性碳 - 13 - 辛酸呼气试验）与空腹血浆胃饥饿素水平相关（r = 0.74，p = 0.0013）。胃饥饿素似乎是在营养摄入、胃运动功能和中枢神经系统之间提供反馈信号的一个可能候选因子。（《内分泌学研究杂志》24：RC19 - RC21，2001年）（C）2001，柯蒂斯出版社
Ghrelin, an endogenous ligand of the GH secretagogue-receptor, has recently been shown to stimulate GH secretion and to have orexigenic and adipogenic effects in rodents, but little is known about its regulation and biological function in humans. Gastric motor function is under control of the central nervous system; however, the afferent and efferent loops of this feedback control mechanism remain to be elucidated. In the study presented here we investigated the effect of nutrient intake on circulating human ghrelin levels, and a possible association between ghrelin levels and gastric emptying. Ten healthy volunteers received a standard meal after an overnight fast. Food intake significantly decreased plasma ghrelin levels from 248.5 +/- 15.0 to 179.5 +/- 17.9 fmol/ml (120 min after meal, p = 0.047). Gastric emptying half-time (non-invasive C-13-octanoic acid breath test) was correlated with fasting plasma ghrelin levels (r = 0.74, p = 0.0013), Ghrelin appears to be one possible candidate to provide feedback signaling between nutrient intake, gastric motor function and the central nervous system, (J, Endocrinol, Invest. 24: RC19-RC21, 2001) (C) 2001, Editrice Kurtis.