Tensor-valued diffusion MRI in under 3 minutes: an initial survey of microscopic anisotropy and tissue heterogeneity in intracranial tumors
Tensor-valued diffusion MRI in under 3 minutes: an initial survey of microscopic anisotropy and tissue heterogeneity in intracranial tumors
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DOI：
10.1002/mrm.27959
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发表时间：
2019-09-13
影响因子：
3.3
通讯作者：
Sundgren, Pia C.
中科院分区：
文献类型：
--
作者：
Nilsson, Markus;Szczepankiewicz, Filip;Sundgren, Pia C.
目的评价基于张量值扩散MRI的3分钟方案评价多种颅内肿瘤显微各向异性和组织异质性的可行性。方法对42例颅内肿瘤（胶质瘤、脑膜瘤、腺瘤和转移瘤）进行B张量编码。分别通过估计各向异性峰度（MKA）和各向同性峰度（MKI）评价显微各向异性和组织异质性。广泛的成像协议进行了比较，3分钟的协议。结果快速成像方案产生的参数在偏倚和精度方面与完整方案相似。胶质母细胞瘤的显微镜各向异性低于脑膜瘤（MKA = 0.29 +/- 0.06 vs. 0.45 +/- 0.08，P = 0.003）。转移瘤的组织异质性（MKI = 0.57 +/- 0.07）高于胶质母细胞瘤（0.44 +/- 0.06，P < 0.001）和脑膜瘤（0.46 +/- 0.06，P = 0.03）。结论在临床相关时间框架内评价颅内肿瘤患者的显微各向异性和组织异质性是可行的。
Purpose To evaluate the feasibility of a 3-minutes protocol for assessment of the microscopic anisotropy and tissue heterogeneity based on tensor-valued diffusion MRI in a wide range of intracranial tumors. Methods B-tensor encoding was performed in 42 patients with intracranial tumors (gliomas, meningiomas, adenomas, and metastases). Microscopic anisotropy and tissue heterogeneity were evaluated by estimating the anisotropic kurtosis (MKA) and isotropic kurtosis (MKI), respectively. An extensive imaging protocol was compared with a 3-minutes protocol. Results The fast imaging protocol yielded parameters with characteristics in terms of bias and precision similar to the full protocol. Glioblastomas had lower microscopic anisotropy than meningiomas (MKA = 0.29 +/- 0.06 vs. 0.45 +/- 0.08, P = 0.003). Metastases had higher tissue heterogeneity (MKI = 0.57 +/- 0.07) than both the glioblastomas (0.44 +/- 0.06, P < 0.001) and meningiomas (0.46 +/- 0.06, P = 0.03). Conclusion Evaluation of the microscopic anisotropy and tissue heterogeneity in intracranial tumor patients is feasible in clinically relevant times frames.