Collagen synthesis during lung development and during hyaline membrane disease in the nonhuman primate.
Collagen synthesis during lung development and during hyaline membrane disease in the nonhuman primate.
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非人灵长类动物肺发育和透明膜疾病期间的胶原合成。
DOI：
10.1164/ajrccm/141.4_pt_1.846
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Hodson,WA
中科院分区：
文献类型：
--
作者：
Jackson,JC;Clark,JG;Standaert,TA;Truog,WE;Murphy,JH;Juul,SE;Chi,EY;Hodson,WA
为了评估胶原合成的成熟变化，取自健康猕猴的肺组织，年龄从足月妊娠的68%到成年不等。我们假设早产的婴儿比年长的动物有更高的胶原合成率，因为他们在怀孕期间肺生长的速度更快。其次，我们假设患有肺透明膜病(HMD)的婴儿的肺修复与肺胶原合成率的增加有关。因此，在生命的第一周，从足月妊娠82%出生的猴子身上获得肺组织，在这个阶段，一半的猴子患上了HMD。测定肺组织总蛋白合成率和胶原合成率，分别测定肺组织中[3 H]Pro掺入率和胶原合成率。早产儿的胶原合成率(9.9±2.7nmol/mg DNA/h)高于足月儿(5.3±1.1)或年龄较大的动物(2.1±0.4，p<；0.05)。HMD动物的胶原合成率在3h(14.3±6.9)~7d(15.1±6.1)无明显增加，对照组早产动物出生后第1周也无明显变化(3h为10.9±3.0；7d为11.6±4.6)。早产儿HMD恢复的早期似乎与胶原生成的增加没有关联，而不是已经增加的与肺生长相关的合成速率。
To assess maturational changes in collagen synthesis, lung tissue was obtained from healthyMacaca nemestrinamonkeys at different ages, ranging from 68% of term gestation to adulthood. We hypothesized that infants delivered prematurely have a greater rate of collagen synthesis than do older animals because of their greater rate of lung growth during gestation. Secondly, we hypothesized that lung repair in infants with hyaline membrane disease (HMD) is associated with an additional increase in lung collagen synthesis rate. Therefore, lung tissue was obtained during the first week of life from monkeys delivered at 82% of term gestation, a stage at which half of them developed HMD. The rate of total protein synthesis in lung samples was determined by measuring the incorporation of [3H]proline; the rate of collagen synthesis was determined by measuring the conversion of proline into hydroxyproline. Premature monkeys had a higher rate of collagen synthesis (9.9 ± 2.7 nmol/mg DNA/h) than did term infants (5.3 ± 1.1) or older animals (2.1 ± 0.4, p < 0.05). There was no additional increase in rate of collagen synthesis in animals with HMD from 3 h (14.3 ± 6.9) to 7 days of age (15.1 ± 6.1); control premature animals also had no significant change during the first week of life (10.9 ± 3.0 at 3 h; 11.6 ± 4.6 at 7 days). The early stage of recovery from HMD in premature monkeys does not appear to be associated with an increase in collagen production beyond the already increased synthesis rate associated with lung growth.
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羊肺、肌腱和皮肤胎儿发育过程中原胶原信使 RNA 水平和活性以及胶原蛋白合成。
影响因子：
4.8
作者：
P. Tolstoshev;R. Haber;B. Trapnell;R. Crystal
通讯作者：
R. Crystal
博来霉素诱导狒狒弥漫性间质性肺纤维化。
影响因子：
15.9
作者：
J. Collins;Bruce McCullough;J. Coalson;W. Johanson
通讯作者：
W. Johanson
DOI：
10.1164/arrd.1983.128.1.82
发表时间：
1983-07
期刊：
The American review of respiratory disease
影响因子：
--
作者：
G. Laurent;R. McAnulty
通讯作者：
G. Laurent;R. McAnulty
影响因子：
4.8
作者：
K. Bradley;S. D. Mcconnell;R. Crystal
通讯作者：
R. Crystal
早产猴实验性透明膜疾病：产前地塞米松的影响。
DOI：
10.1164/arrd.1982.126.1.62
发表时间：
1982
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Kessler,DL;Truog,WE;Murphy,JH;Palmer,S;Standaert,TA;Woodrum,DE;Hodson,WA
通讯作者：
Hodson,WA