Measles, Mumps, and Rubella Titers in Air Force Recruits Below Herd Immunity Thresholds?
Measles, Mumps, and Rubella Titers in Air Force Recruits Below Herd Immunity Thresholds?
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DOI：
10.1016/j.amepre.2015.04.019
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发表时间：
2015-11-01
影响因子：
5.5
通讯作者：
Webber, Bryant J.
中科院分区：
文献类型：
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作者：
Lewis, Paul E.;Burnett, Daniel G.;Webber, Bryant J.
简介：尽管有有效的疫苗，但麻疹和腮腺炎等易感染疾病在美国的发生频率越来越高。考虑到可能在新兵中爆发流行病，我们将新兵中麻疹、腮腺炎和风疹免疫的血清学证据与已知的群体免疫阈值进行了比较，并确定了目前国防部基于麻疹和风疹滴度推定腮腺炎免疫的政策是否可靠。方法：2013年4月25日至2014年4月24日，在抵达德克萨斯州圣安东尼奥-拉克兰联合基地时，从所有新兵中获得麻疹、腮腺炎和风疹的血清抗体水平。根据年龄和性别评估每种疾病的血清阳性率，并计算腮腺炎滴度与麻疹和风疹滴度之间的一致性。结果：32,502名新兵麻疹、流行性腮腺炎和风疹抗体阳性率分别为81.6%、80.3%和82.1%。在22,878新兵麻疹和风疹抗体血清阳性，87.7%也是血清阳性腮腺炎。结论：麻疹，腮腺炎，风疹抗体血清阳性的一个大队列的新兵进入美国空军基本训练普遍低于保持群体免疫力所需的水平。为了减少腮腺炎感染的发生率，国防部应考虑获得麻疹、腮腺炎和风疹的抗体滴度，并为所有易感染一种或多种病毒的人接种疫苗。爱思唯尔公司出版美国预防医学杂志（American Journal of Preventive Medicine）
Introduction: Preventable diseases like measles and mumps are occurring with increasing frequency in the U.S. despite the availability of an effective vaccine. Given concern that an outbreak may occur among military recruits, we compared serologic evidence of immunity to measles, mumps, and rubella among military recruits with known herd immunity thresholds and determined whether the current Department of Defense policy of presuming mumps immunity based on measles and rubella titers is reliable.Methods: Serum antibody levels for measles, mumps, and rubella were obtained from all new recruits upon arrival at Joint Base San Antonio-Lackland, Texas, from 25 April 2013 through 24 April 2014. Seroprevalence of each disease was assessed by age and sex, and concordance between mumps titers and measles and rubella titers was calculated. Data analysis was performed in 2014 2015.Results: Among 32,502 recruits, seroprevalences for measles, mumps, and rubella antibodies were 81.6%, 80.3%, and 82.1%, respectively. Of the 22,878 recruits seropositive for both measles and rubella antibodies, 87.7% were also seropositive for mumps.Conclusions: Seroprevalences for measles, mumps, and rubella antibodies among a large cohort of recruits entering U.S. Air Force basic training were generally lower than levels required to maintain herd immunity. In order to reduce the incidence of mumps infections, the Department of Defense should consider obtaining antibody titers for measles, mumps, and rubella and vaccinating all individuals susceptible to one or more of the viruses. Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine