Ferroptosis: New Dawn for Overcoming the Cardio-Cerebrovascular Diseases.

Ferroptosis: New Dawn for Overcoming the Cardio-Cerebrovascular Diseases.
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铁死亡:攻克心脑血管疾病的新曙光。

DOI:
10.3389/fcell.2021.733908
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发表时间:
2021
影响因子:
5.5
通讯作者:
Tian Y
Tian Y
中科院分区:
生物学2区
文献类型:
--
作者:
Luo MY;Su JH;Gong SX;Liang N;Huang WQ;Chen W;Wang AP;Tian Y

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心肌细胞和神经元的动态平衡对维持心脏和大脑的正常生理功能至关重要。如果组织中过多的细胞死亡,就会发生严重的心脑血管疾病,即高血压、心肌梗死和缺血性中风。细胞死亡的调节在促进或减轻脑血管疾病中起作用。铁凋亡是一种铁依赖性的新型细胞死亡,已被证明发生在多种疾病中。本文就铁凋亡及其调控机制在脑血管病中的作用进行综述,并探讨铁凋亡相关抑制剂的重要作用,以期为脑血管病的防治提供新的思路。
The dynamic balance of cardiomyocytes and neurons is essential to maintain the normal physiological functions of heart and brain. If excessive cells die in tissues, serious Cardio-Cerebrovascular Diseases would occur, namely, hypertension, myocardial infarction, and ischemic stroke. The regulation of cell death plays a role in promoting or alleviating Cardio-Cerebrovascular Diseases. Ferroptosis is an iron-dependent new type of cell death that has been proved to occur in a variety of diseases. In our review, we focus on the critical role of ferroptosis and its regulatory mechanisms involved in Cardio-Cerebrovascular Diseases, and discuss the important function of ferroptosis-related inhibitors in order to propose potential implications for the prevention and treatment of Cardio-Cerebrovascular Diseases.
选择性铁死亡抑制剂 Liproxstatin-1 可减轻蛛网膜下腔术后神经功能缺损和神经炎症
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