COLON-CANCER AND SERUM VITAMIN-D METABOLITE LEVELS 10-17 YEARS PRIOR TO DIAGNOSIS
COLON-CANCER AND SERUM VITAMIN-D METABOLITE LEVELS 10-17 YEARS PRIOR TO DIAGNOSIS
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DOI：
10.1093/oxfordjournals.aje.a117682
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发表时间：
1995-09-15
影响因子：
5
通讯作者：
COMSTOCK, GW
中科院分区：
文献类型：
--
作者：
BRAUN, MM;HELZLSOUER, KJ;COMSTOCK, GW
这项研究检验了低血清维生素D代谢物水平与结肠癌风险增加相关的假设。从1974年8月到11月，马里兰州华盛顿县的20,305名居民捐献了血液，储存在-70 ℃的血清库中。在1984-1991年期间，这些居民中有57人后来被诊断出结肠癌。对照组在1974年捐献了血液，直到诊断出该病例为止，一直没有患结肠癌。在年龄（+/-1岁）、种族、性别和抽血日期（+/-1个月）方面，将两名对照与每例病例匹配。病例组和对照组的平均25-羟维生素D水平分别为23.6 ng/ml和23.2 ng/ml，平均1，25-二羟维生素D水平分别为34.7 pg/ml和34.6 pg/ml。通过血清水平的五分位数分析同样发现，比值比的95%置信区间均不排除1，并且未观察到剂量反应效应。我们的数据没有提供强有力的支持维生素D代谢物水平影响结肠癌风险的假设。
This study examines the hypothesis that low serum levels of vitamin D metabolites are associated with an increased risk for colon cancer. From August through November 1974, 20,305 residents of Washington County, Maryland, donated blood for storage at -70 degrees C in a serum bank. Colon cancer was subsequently diagnosed among 57 of these residents during the period 1984-1991. Controls had donated blood in 1974 and remained free of colon cancer through the date of diagnosis of the case. Two controls were matched to each case on age (+/-1 year), race, sex, and date of blood draw (+/-1 month). Mean 25-hydroxyvitamin D levels were 23.6 ng/ml and 23.2 ng/ml, and mean 1,25-dihydroxyvitamin D levels were 34.7 pg/ml and 34.6 pg/ml, in cases and controls, respectively. Analysis by quintile of serum level similarly found that none of the 95% confidence intervals of the odds ratios excluded unity, and a dose-response effect was not observed. Our data provide no strong support for the hypothesis that vitamin D metabolite levels affect the subsequent risk for colon cancer.