Bioactive triterpenoids from Sambucus javanica Blume
Bioactive triterpenoids from Sambucus javanica Blume
复制标题
爪哇接骨木中的生物活性三萜类化合物
DOI：
10.1080/14786419.2019.1596092
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发表时间：
2019-04-08
影响因子：
2.2
通讯作者：
Wang, Wen-Jing
中科院分区：
文献类型：
--
作者：
Chen, Feilong;Liu, Dong-Li;Wang, Wen-Jing
从接骨木地上部分分离得到一个新的三萜类化合物--爪哇草素A(1)和6个已知化合物。分别鉴定为3β，23-二羟基-11α，12α-环氧基-URS-20(30)-烯-28，13β-内酯(1)，熊果酸(2)，柚酸(3)，齐墩果酸(4)，2α-羟基齐墩果酸(5)，α-香兰素(6)，羽扇豆醇棕榈酸酯(7)。化合物1和3对脂多糖(LPS)激活的RAW264.7巨噬细胞株产生一氧化氮(NO)有抑制作用，IC50值分别为17.4和26.2mU。
A new triterpene, javablumine A (1) along with six known ones were isolated from the aerial parts of Sambucus javanica Blume. They were identified as 3 beta,23-dihydroxy-11 alpha,12 alpha-epoxy-urs-20(30)-en-28,13 beta-olide (1), ursolic acid (2), pomolic acid (3), oleanic acid (4), 2 alpha-hydroxy-oleanolic acid (5), alpha-amyrin (6), and lupeol palmitate (7), respectively. Compounds 1 and 3 exhibited inhibitory effect against nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW264.7 macrophage cell lines with IC50 values of 17.4 and 26.2 mu M, respectively.[GRAPHICS].