Regulation of Presynaptic Calcium Channels.
Regulation of Presynaptic Calcium Channels.
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突触前钙通道的调节。
DOI：
10.1007/978-3-031-34229-5_7
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发表时间：
2023
影响因子：
--
通讯作者：
Yue,Lixia
中科院分区：
文献类型：
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作者：
Zong,Pengyu;Yue,Lixia
电压门控钙通道 (VGCC)，尤其是 Cav2.1 和 Cav2.2，是响应神经元兴奋而在突触前膜处 Ca2+ 内流的主要介质，从而对突触传递发挥主要控制作用。为了保证突触神经递质的及时、精确释放，突触前VGCC的活性受到多种因素的严格调控，包括辅助亚基、膜电位、G蛋白偶联受体（GPCR）、钙调蛋白（CaM）、Ca2+结合蛋白（CaBP）、蛋白激酶、各种相互作用蛋白、选择性剪接事件和遗传变异。
Voltage-gated calcium channels (VGCCs), especially Cav2.1 and Cav2.2, are the major mediators of Ca2+influx at the presynaptic membrane in response to neuron excitation, thereby exerting a predominant control on synaptic transmission. To guarantee the timely and precise release of neurotransmitters at synapses, the activity of presynaptic VGCCs is tightly regulated by a variety of factors, including auxiliary subunits, membrane potential, G protein-coupled receptors (GPCRs), calmodulin (CaM), Ca2+-binding proteins (CaBP), protein kinases, various interacting proteins, alternative splicing events, and genetic variations.