Beyond energy storage: roles of glycogen metabolism in health and disease.
Beyond energy storage: roles of glycogen metabolism in health and disease.
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超越能量储存：糖原代谢在健康和疾病中的作用。
DOI：
10.1111/febs.15648
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发表时间：
2020
期刊：
影响因子：
5.4
通讯作者：
Huang Bo
中科院分区：
文献类型：
--
作者：
Zhang Huafeng;Ma Jingwei;Tang Ke;Huang Bo
除了在肝脏和肌肉中储存和供应能量外，在各种生理和病理生理条件下，糖原还在细胞分化、信号转导、氧化还原调节和茎的形成等方面发挥关键作用。糖原储存疾病的各种形式已经揭示了这种多功能的功能。在这里，我们概述了糖原代谢中碳流的来源，并讨论了糖原代谢如何引导CD8+T细胞记忆的形成和维持。同样，我们回顾了这如何影响巨噬细胞极化和炎症反应。此外，我们剖析了糖原代谢如何通过促进肿瘤再生细胞在低氧肿瘤微环境中的生长来支持肿瘤的发展。这篇综述强调了gluconeogenesis‐glycogenesis‐glycogenolysis‐PPP代谢链在氧化还原动态平衡中的重要作用，从而为包括癌症在内的主要慢性疾病的潜在治疗策略提供了见解。
Beyond storing and supplying energy in the liver and muscles, glycogen also plays critical roles in cell differentiation, signaling, redox regulation, and stemness under various physiological and pathophysiological conditions. Such versatile functions have been revealed by various forms of glycogen storage diseases. Here, we outline the source of carbon flux in glycogen metabolism and discuss how glycogen metabolism guides CD8+T‐cell memory formation and maintenance. Likewise, we review how this affects macrophage polarization and inflammatory responses. Furthermore, we dissect how glycogen metabolism supports tumor development by promoting tumor‐repopulating cell growth in hypoxic tumor microenvironments. This review highlights the essential role of the gluconeogenesis‐glycogenesis‐glycogenolysis‐PPP metabolic chain in redox homeostasis, thus providing insights into potential therapeutic strategies against major chronic diseases including cancer.