Higher Plasma S100B Concentrations in Schizophrenia Patients, and Dependently Associated with Inflammatory Markers
Higher Plasma S100B Concentrations in Schizophrenia Patients, and Dependently Associated with Inflammatory Markers
复制标题
DOI：
10.1038/srep27584
复制
发表时间：
2016-06-09
影响因子：
4.6
通讯作者：
Xie, Bin
中科院分区：
文献类型：
--
作者：
Hong, Wu;Zhao, Min;Xie, Bin
神经胶质细胞损伤和免疫功能障碍参与了精神分裂症的发病机制。然而，精神分裂症中神经胶质细胞损伤和免疫功能障碍之间的相互作用尚不明确。本研究旨在比较精神分裂症患者和健康受试者血浆S100钙结合蛋白(S100B)的水平，并确定免疫标志物是否与精神分裂症患者S100B的浓度独立相关。入选精神分裂症患者41例，健康志愿者33例。采用酶联免疫吸附试验(EL ISA)检测血浆S100B和炎症标志物的浓度。我们发现精神分裂症患者的S100B浓度高于健康受试者(p<0.046)，且与症状的严重程度呈负相关(p=0.05)。受试者工作特征曲线分析显示，精神分裂症患者与健康受试者S100B水平不同可作为临床诊断因素(预测值：0.666，p=0.015)。多元线性回归分析发现，病程(β=-0.161)、血浆炎症调节因子(包括转化生长因子β1、对数IL-23和对数IL-10)水平(β=0.119、0.475、0.514)与S100B浓度独立相关(调整后R-2=0.897，p<；0.001)。因此，我们的结果提示S100B可能在精神分裂症的发病机制中发挥作用，并提示自身免疫反应和平衡在精神分裂症患者神经胶质功能障碍中的重要作用。
Glial damage and immune dysfunction are involved in pathogenesis of schizophrenia. However, interaction between glial damage and immune dysfunction in schizophrenia is undefined. This study aims to compare plasma S100 calcium binding protein (S100B) levels between schizophrenia patients and healthy participants, and to determine if immune markers are independently related with concentration of S100B in schizophrenia patients. Forty-one schizophrenia patients and thirty-three healthy volunteers were enrolled. Enzyme-linked immunosorbent assay (ELISA) was used to assess the concentrations of plasma S100B and inflammatory markers. We found that concentrations of S100B were elevated in schizophrenia patients than healthy participants (p < 0.05), and were negatively related with the severity of symptoms (p = 0.046). Receiver operating characteristic (ROC) curve analysis showed that different S100B levels between schizophrenia and healthy participants can be used as a clinical diagnostic factor (predictive value: 0.666, p = 0.015). Multiple linear regression analysis found that length of illness (Beta = -0.161), plasma levels of inflammatory regulation factors (including TGF-beta 1, logIL-23 and logIL-10) (Beta = 0.119, 0.475, 0.514) were independently associated with concentrations of S100B (Adjusted R-2 = 0.897, p < 0.001). Therefore, our results suggest the possible function of S100B in pathogenesis of schizophrenia, and implicate the important role of autoimmune response and balance to glial dysfunction in patients with schizophrenia.