[Efficacy and mechanism of puerin Ⅰ in improving disorder of glycolipid metabolism in ApoE-/-mice].
[Efficacy and mechanism of puerin Ⅰ in improving disorder of glycolipid metabolism in ApoE-/-mice].
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DOI：
10.19540/j.cnki.cjcmm.20180323.001
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发表时间：
2018-06-01
期刊：
影响因子：
--
通讯作者：
Tu, Peng-Fei
中科院分区：
文献类型：
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作者：
Gu, Xiao-Pan;Wu, Zhen;Tu, Peng-Fei
普洱茶是由山茶嫩叶加工而成的一种独特的后发酵茶。普洱茶中葛根素Ⅰ（P1）是普洱茶微生物发酵过程中产生的特征性成分，本研究旨在探讨普洱茶中葛根素Ⅰ（P1）对ApoE-/-小鼠血脂异常和糖尿病的治疗作用及其机制。结果表明，P1能显著降低高脂血症和高血糖ApoE-/-小鼠的总胆固醇（TC）、甘油三酯（TG）和空腹血糖（FBG），改善糖耐量异常（IPGTT）和胰岛素敏感性（ITT）。进一步的实验证明，P1分别通过抑制肠道α-糖苷酶活性和激活低密度脂蛋白受体来降低FBG和血浆TG水平。本研究证实了P1对ApoE-/-小鼠糖尿病和高脂血症的治疗作用及其机制。基于该化合物的良好疗效，P1有望成为治疗糖脂代谢紊乱的新药。
Pu-erh tea is a unique post-fermented tea processed from tender leaves of Camellia assamica. Characteristic component puerins were produced during the microbial fermentation process.This study focuses on the therapeutic effect and mechanism of puerinⅠ(P1) in Pu-erh tea on ApoE-/- mice with dyslipidemia and diabetes. It was found that P1 could significantly decreased total cholesterol (TC), triglyceride (TG) and fast blood glucose (FBG), and markedly improved impaired glucose tolerance (IPGTT) and insulin sensitivity (ITT) in hyperlipidemic and hyperglycemic ApoE-/- mice. Further experiments proved that P1 reduced FBG and plasma TG levels by inhibiting intestinal alpha-glycosidase enzymes activity and by activating low-density lipoprotein receptor respectively. This study confirmed the therapeutic effect and mechanism of P1 on ApoE-/- mice with diabetes and hyperlipidemia. Based on the good efficacy of this compound, P1 could be used as a new drug to treat the disorder of glycolipid metabolism.