FUNCTIONAL DISTRIBUTION OF RIGHT AND LEFT STELLATE INNERVATION TO VENTRICLES - PRODUCTION OF NEUROGENIC ELECTROCARDIOGRAPHIC CHANGES BY UNILATERAL ALTERATION OF SYMPATHETIC TONE
FUNCTIONAL DISTRIBUTION OF RIGHT AND LEFT STELLATE INNERVATION TO VENTRICLES - PRODUCTION OF NEUROGENIC ELECTROCARDIOGRAPHIC CHANGES BY UNILATERAL ALTERATION OF SYMPATHETIC TONE
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DOI：
10.1161/01.res.18.4.416
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发表时间：
1966-01-01
影响因子：
20.1
通讯作者：
ABILDSKO.JA
中科院分区：
文献类型：
--
作者：
YANOWITZ, F;PRESTON, JB;ABILDSKO.JA
在开胸狗准备中进行单侧星状神经节刺激或消融后，测量心电图和心室不应期的变化。右侧星状神经节切除术或左侧星状神经节刺激会产生 Q-T 间期延长和 T 波振幅增加。左星状神经节切除术或右星状神经节刺激会产生 T 波负性增加，但 Q-T 间期没有可测量的变化。由左右星状神经支配介导的交感神经张力变化引起的心电图波形的不同模式可能与心室不应期的变化相关。右星状神经节切除术后，不应期延长在前心室表面最为明显；左星状神经节切除术在后表面产生最大的延长。尽管心室的左右星状神经支配重叠，但左星状影响在心室后壁上占主导地位，而右星状影响在心室前壁上占主导地位。单侧交感神经张力改变后观察到的心电图形式变化与中枢神经系统病变患者中观察到的心电图异常相似，这表明这些临床发现可能具有功能性解释。
Changes of the ecg and of ventricular refractory period were measured following either unilateral stellate ganglion stimulation or ablation in the open chest dog preparation. Right stellate ganglionectomy or left stellate stimulation produces prolonged Q-T intervals and increased T-wave amplitude. Left stellate ganglionectomy or right stellate stimulation produces increased T-wave negativity without measurable change in the Q-T interval. The differing patterns of ecg wave form resulting from changes in sympathetic tone mediated by right and left stellate innervation could be correlated with changes in ventricular refractory period. Following right stellate ganglionectomy, refractory period prolongations were most marked over the anterior ventricular surface; left stellate ganglionectomy produced the greatest prolongation on the posterior surface. Although the right and left stellate innervations of the ventricles overlap, the left stellate influence is predominant over the posterior wall of the ventricles, while right stellate influence dominates the anterior ventricular wails. The ecg form changes observed following unilateral alteration of sympathetic tone paralleled those ecg abnormalities seen in patients with lesions of the central nervous system, suggesting a possible functional explanation for these clinical findings.