Stalking the schizovirus.
Stalking the schizovirus.
复制标题
追踪精神分裂病毒。
作者：
E. Torrey
一些精神分裂症病例是由中枢神经系统的慢性感染过程引起的可能性正在探索中。这一假说在19世纪早期很流行，随着人们对病毒的某些特性（如嗜神经性、潜伏性和在不影响细胞结构的情况下改变细胞酶的能力）的进一步了解，这一假说又重新流行起来。从理论上讲，精神分裂症可能是由子宫内或发病年龄前的任何时间发生的感染引起的。对某些精神分裂症病例可能的病毒病因的研究正在使用间接方法（精神分裂症出生的季节性、患病率研究、免疫异常、抗精神病药物的抗病毒作用和对同卵双胞胎的研究）和直接方法（神经病理学、向实验动物的传播以及病毒基因组、抗原或抗体的检测）进行。
The possibility that some cases of schizophrenia are caused by a chronic infectious process of the central nervous system is being explored. This hypothesis was popular in the early years of the 19th century and has been revived as certain properties of viruses have become better understood (e.g., neurotropism, latency, and ability to alter cell enzymes without affecting cell structure). Schizophrenia could theoretically be caused by infections occurring either in utero or at any time up to the age of onset. Research on a possible viral etiology of some cases of schizophrenia is being carried out using both indirect measures (seasonality of schizophrenic births, prevalence studies, immunological abnormalities, antiviral effects of antipsychotic drugs, and studies of identical twins) as well as direct measures (neuropathology, transmission to laboratory animals, and detection of the viral genome, antigen, or antibody).