Lack of Prognostic Significance of BCL2 and p53 Protein Overexpression in Elderly Patients with Diffuse Large B-cell Non-Hodgkin's Lymphoma: Results from a Population-based Non-Hodgkin's Lymphoma Registry
Lack of Prognostic Significance of BCL2 and p53 Protein Overexpression in Elderly Patients with Diffuse Large B-cell Non-Hodgkin's Lymphoma: Results from a Population-based Non-Hodgkin's Lymphoma Registry
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BCL2 和 p53 蛋白过度表达在老年弥漫性大 B 细胞非霍奇金淋巴瘤患者中缺乏预后意义：基于人群的非霍奇金淋巴瘤登记结果
DOI：
10.1080/1042819031000147009
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发表时间：
2004
影响因子：
2.6
通讯作者：
E. Noordijk
中科院分区：
文献类型：
--
作者：
E. Maartense;M. Kramer;S. le Cessie;J. Kluin;P. Kluin;S. Snijder;E. Noordijk
本文研究了372例弥漫大B细胞性非霍奇金淋巴瘤患者年龄对预后的影响，并与bcl2和P53蛋白高表达的预后因素进行了比较。Bcl2和p5 3癌基因蛋白的过度表达定义为肿瘤细胞中bcl2和p5 3蛋白表达阳性。根据 65岁和⩾65岁这两个年龄组对数据进行了分析。在65岁以上的患者中，bcl2的过度表达有明显增加的趋势(P = 0.065)。Bcl2过表达患者的无瘤生存率显著低于65岁以下的患者(对数等级检验P = 0.0002)，并且bcl2过表达也具有独立的预后意义(P <； 0.001)。P53蛋白高表达组的完全缓解率(P = 0.0 1)和5年生存率(对数等级检验P = 0.0 4)均有显著差异(P<0.0 1)。当对接受过适当治疗的老年患者重复分析时，发现bcl2和p53同样缺乏意义。这项研究表明，bcl2和p53蛋白过度表达对65岁以上患者的负面预后价值并不令人担忧。在老年患者中，国际预后指数评分似乎是预后较差的主要危险因素。
The prognostic significance of age was studied in 372 patients with diffuse large B-cell non-Hodgkin's lymphoma, in relation to the prognostic factors of overexpressed BCL2 and p53 oncoprotein. Overexpression of BCL2 and p53 oncoprotein was defined when more than 50% of the tumor cells showed positive staining. The data were analyzed with respect to the age groups < 65 and ⩾ 65 years of age. There was a trend for BCL2 overexpression to occur significantly more often among patients older than 65 years of age (P = 0.065). Patients with BCL2 overexpression showed significantly inferior disease free survival rate, but only for patients younger than 65 years (log-rank test P = 0.0002), and the overexpression showed also an independent prognostic significance (P < 0.001). With respect to overexpressed p53 a significant difference was reached for complete remission rate (P = 0.01) and 5-year survival rate (log-rank test P = 0.04), again only for the younger age group. When the analyses were repeated for the older patients who had been treated adequately, the same lack of significance was found, both for BCL2 and p53. This study demonstrates that the negative prognostic value of overexpressed BCL2 and p53 protein is not of concern for patients older than 65 years of age. Among elderly patients the International Prognostic Index score seems the predominant risk factor for inferior prognosis.
影响因子：
158.5
作者：
Rosenwald, A;Wright, G;Staudt, LM
通讯作者：
Staudt, LM
Bcl-2 蛋白表达和 Bcl-2 基因重排在弥漫性侵袭性非霍奇金淋巴瘤中的预后意义。
影响因子：
20.3
作者：
Gascoyne,RD;Adomat,SA;Krajewski,S;Krajewska,M;Horsman,DE;Tolcher,AW;O'Reilly,SE;Hoskins,P;Coldman,AJ;Reed,JC;Connors,JM
通讯作者：
Connors,JM