Syphilis and HIV: a dangerous duo.
Syphilis and HIV: a dangerous duo.
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DOI：
10.1586/14787210.3.5.825
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发表时间：
2005-10-01
影响因子：
5.7
通讯作者：
Augenbraun, Michael
中科院分区：
文献类型：
--
作者：
Karumudi, Usha Rani;Augenbraun, Michael
艾滋病毒和梅毒影响相似的患者群体，合并感染很常见。所有梅毒患者都应接受艾滋病毒检测，反之亦然。梅毒可以增强艾滋病毒的传播。梅毒的检测和治疗可能有助于减少艾滋病毒的传播。梅毒在HIV阳性患者中可能表现为非典型特征，例如，无症状一期梅毒的比例较高，而更多的HIV阳性患者表现为继发性疾病。继发性感染可能更具侵袭性，早期神经系统和眼科受累率增加。诊断通常是通过血清学，但临床医生应该意识到假阴性血清学的可能性，无论是在一期梅毒，并不常见，在二期梅毒。所有HIV阳性患者均应接受以青霉素为基础的治疗方案，并应谨慎使用替代疗法。所有HIV阳性患者都应考虑神经梅毒的评估。复发是一个真实的问题，需要仔细随访。本综述将探讨HIV合并感染者临床表现的差异，并将讨论数据，以保证不同的管理HIV合并感染者。
HIV and syphilis affect similar patient groups and coinfection is common. All patients presenting with syphilis should be offered HIV testing and vice versa. Syphilis can enhance the transmission of HIV. Detection and treatment of syphilis can probably help to reduce HIV transmission. Syphilis may present with atypical features in the HIV-positive patient, for example, there is a higher rate of asymptomatic primary syphilis, and proportionately more HIV-positive patients present with secondary disease. Secondary infection may be more aggressive and there is an increased rate of early neurologic and ophthalmic involvement. Diagnosis is generally made with serology, but the clinician should be aware of the potential for false-negative serology in both primary and, less commonly, in secondary syphilis. All HIV-positive patients should be treated with a penicillin-based regimen, and alternative therapies should be used with caution. All HIV-positive patients should be considered for the evaluation of neurosyphilis. Relapse is a real concern and careful follow up is required. This review will explore the differences in clinical manifestations in HIV-coinfected individuals, and will discuss data to warrant different management in HIV-coinfected individuals.