From peroxisomal disorders to common neurodegenerative diseases - the role of ether phospholipids in the nervous system.
From peroxisomal disorders to common neurodegenerative diseases - the role of ether phospholipids in the nervous system.
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DOI：
10.1002/1873-3468.12788
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发表时间：
2017-09
期刊：
影响因子：
3.5
通讯作者：
Berger J
中科院分区：
文献类型：
--
作者：
Dorninger F;Forss-Petter S;Berger J
醚（磷酸）脂质在神经系统发育以及健康和疾病功能中的新兴多种作用目前引起了越来越多的兴趣。缩醛磷脂是醚脂的一个亚类，是参与囊泡融合和膜筏组成的重要膜成分。它们储存多不饱和脂肪酸，可以作为抗氧化剂。醚类脂质代谢物充当糖基-磷脂酰-肌醇锚形成的前体；其他的，如血小板激活因子，则与信号传导功能有关。整合现有信息，我们试图通过将醚脂的个体功能特性与病理特征联系起来，为缺乏醚脂的人类患者和小鼠的戏剧性神经表型提供分子解释。此外，最近的出版物已经发现，在许多获得性神经系统疾病（包括阿尔茨海默病（AD）和自闭症）的背景下，醚脂水平发生了变化。最后，对目前在过氧化物酶体疾病和 AD 中恢复醚脂质的努力进行了严格审查。
The emerging diverse roles of ether (phospho)lipids in nervous system development and function in health and disease are currently attracting growing interest. Plasmalogens, a subgroup of ether lipids, are important membrane components involved in vesicle fusion and membrane raft composition. They store polyunsaturated fatty acids and may serve as antioxidants. Ether lipid metabolites act as precursors for the formation of glycosyl-phosphatidyl-inositol anchors; others, like platelet-activating factor, are implicated in signaling functions. Consolidating the available information, we attempt to provide molecular explanations for the dramatic neurological phenotype in ether lipid-deficient human patients and mice by linking individual functional properties of ether lipids with pathological features. Furthermore, recent publications have identified altered ether lipid levels in the context of many acquired neurological disorders including Alzheimer’s disease (AD) and autism. Finally, current efforts to restore ether lipids in peroxisomal disorders as well as AD are critically reviewed.
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影响因子：
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