Effects of combined therapy with resveratrol, continuous and interval exercises on apoptosis, oxidative stress, and inflammatory biomarkers in the liver of old rats with non-alcoholic fatty liver disease
Effects of combined therapy with resveratrol, continuous and interval exercises on apoptosis, oxidative stress, and inflammatory biomarkers in the liver of old rats with non-alcoholic fatty liver disease
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DOI：
10.1080/13813455.2018.1441872
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发表时间：
2019-03-15
影响因子：
3
通讯作者：
Mazaheri, Zohreh
中科院分区：
文献类型：
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作者：
Hajighasem, Amir;Farzanegi, Parvin;Mazaheri, Zohreh
内容：非酒精性脂肪性肝病（non-alcoholic fatty liver disease，NAFLD）是最常见的慢性肝病。目的：观察白藜芦醇联合间歇运动和持续运动对NAFLD大鼠肝脏氧化应激、炎症反应和细胞凋亡的影响。将NAFLD大鼠分为患者组、生理盐水组、白藜芦醇（RSV）组、持续运动组、间歇运动组、持续运动+ RSV组和间歇运动+ RSV组。单独补充白藜芦醇或与间歇和连续训练相结合显著降低了丙二醛和TNF-α水平（p <0.05），而过氧化氢酶、超氧化物歧化酶和IL-10水平显著增加（p <0.05）。虽然RSV单独使用可显著降低凋亡细胞的百分比，（17.12%），其与间隔的组合（10.74%），且持续（14.85%）运动训练组具有较强的抗凋亡活性结论：虽然白藜芦醇单独具有抗氧化、抗凋亡和抗炎特性，但与间隔联合治疗，持续训练可以更有效地减轻NAFLD患者的这些异常。
Context: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder.Objective: Effects of combined therapy with resveratrol, interval and continuous exercises on oxidative stress, inflammation, and apoptosis in the liver of rats with NAFLD.Methods: NAFLD rats were organised in patient, saline, resveratrol (RSV), continuous exercise, interval exercise, continuous exercise + RSV, and interval exercise + RSV groups.Results: Resveratrol supplementation alone or in combination with interval and continuous training significantly decreased malondialdehyde and TNF-alpha level (p < .05), while the levels of catalase; superoxide dismutase and IL-10 were significantly increased (p < .05). Although RSV alone significantly decreased the percentage of apoptotic cells (17.12%), its combination with interval (10.74%), and continuous (14.85%) exercise training demonstrated higher anti-apoptotic activity (p < .05).Conclusions: Although resveratrol alone has an antioxidant, anti-apoptotic and anti-inflammatory properties, combined therapy with interval, and continuous training can be more effective to mitigate these abnormalities in NAFLD patients.