Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue
Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue
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DOI：
10.1093/jn/131.11.2932
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发表时间：
2001-11-01
影响因子：
4.2
通讯作者：
Miyazawa, T
中科院分区：
文献类型：
--
作者：
Asai, A;Miyazawa, T
姜黄素及其结构相关化合物(姜黄素)是姜黄酚黄色色素，具有抗氧化、抗癌和降胆固醇等活性。在本研究中，我们观察了日粮中添加姜黄素[商品级姜黄素：姜黄素(73.4%)、去甲氧基姜黄素(16.1%)和双去甲氧基姜黄素(10.5%)]对大鼠脂代谢的影响。雄性SD大鼠分为3组(n=6)，饲喂中高脂饲料(豆油15g/100g饲料)2wk。一组不补充补充剂(CONT)，另一组添加0.2g姜黄素/100g日粮(CUR0.2)或1.0g姜黄素/100g日粮(CURI.0)。CUR1.0组大鼠肝脏三酰甘油和胆固醇浓度显著低于CONT组大鼠。CUR1.0组大鼠血浆极低密度脂蛋白部分的三酰甘油也低于CONT组(P<；0.05)。CUR0.2和CUR1.0大鼠的肝酰辅酶A氧化酶活性均显著高于CONT大鼠。此外，随着姜黄素的摄入，附睾脂肪组织重量显著减少，且呈剂量依赖关系。这些结果表明，饮食中的姜黄素类化合物在体内具有降脂功效，可能是由于改变了脂肪酸代谢。
Curcumin and its structurally related compounds (curcuminoids), the phenolic yellowish pigments of turmeric, display antioxidative, anticarcinogenic and hypocholesterolemic activities. In this study, we investigated the effects of dietary supplemented curcuminoids [commercial grade curcumin: a mixture of curcumin (73.4%), demethoxycurcumin (16.1%) and bisdemethoxycurcumin (10.5%)] on lipid metabolism in rats. Male Sprague-Dawley rats were assigned to three diet groups (n = 6) and fed a moderately high-fat diet (15 g soybean oil/100 g diet) for 2 wk. One diet group did not receive supplements (CONT), while the others were supplemented with 0.2 g curcuminoids/100 g diet (CUR0.2) or 1.0 g curcuminoids/100 g diet (CURI.0). Liver triacylglycerol and cholesterol concentrations were significantly lower in CUR1.0 rats than in CONT rats. Plasma triacylglycerols in the VLDL fraction were also lower in CUR1.0 rats than in CONT rats (P < 0.05). Hepatic acyl-CoA oxidase activity of both the CUR0.2 and CUR1.0 rats was significantly higher than that of CONT rats. Furthermore, epididymal adipose tissue weight was significantly reduced with curcuminoid intake in a dose-dependent manner. These results indicate that dietary curcuminoids have lipid-lowering potency in vivo, probably due to alterations in fatty acid metabolism.