The association between heme oxygenase-1 gene promoter polymorphism and the outcomes of catheter ablation of atrial fibrillation.
The association between heme oxygenase-1 gene promoter polymorphism and the outcomes of catheter ablation of atrial fibrillation.
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DOI：
10.1371/journal.pone.0056440
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Chen SA
中科院分区：
文献类型：
--
作者：
Hu YF;Lee KT;Wang HH;Ueng KC;Yeh HI;Chao TF;Liao JN;Lin YJ;Chang SL;Lo LW;Tuan TC;Li CH;Chung FP;Hsu CP;Chang HH;Huang CH;Chen SA
A length polymorphism of GT repeats in the promoter region of the human heme oxygenase-1 (HO-1) gene modulates its gene transcription to protect against myocardial injury. The present study investigated the association between HO-1 promoter polymorphisms and the outcomes of catheter ablation of atrial fibrillation (AF). The allelic frequencies of GT repeats in the HO-1 gene promoter were screened in 205 random individuals who underwent catheter ablation for drug refractory AF.In the patients who received catheter ablation, those with AF recurrence had fewer GT repeats (53.4±7.1 vs. 56.1±6.5, p = 0.004), a lower incidence of hyperlipidemia, more non-paroxysmal AF, and a larger left atrial diameter. After conducting a multivariate logistic analysis, the number of GT repeats (Odds ratio: 0.94, 95% CI 0.90–0.99, p = 0.01) and the diameter of the left atrium (Odds ratio: 1.08, 95% CI 1.02–1.15, p = 0.01) remained independent predictors. The carriers of GT repeats, which were <29 in both alleles, were associated with a lower sinus maintenance rate after catheter ablation (38.5% vs. 60.1%, p = 0.003). The patients were divided into paroxysmal and non-paroxysmal AF groups; the number of GT repeats was associated with AF recurrence only in the patients with paroxysmal AF. The number of GT repeats, combined with LAD, was significant for predicting AF recurrence after catheter ablation (p = 0.01). The number of GT repeats was not found to be associated with differences in the left atrial diameter, the biatrial voltage, or the levels of bilirubin, ferritin, iron, C-reactive protein, or von-Willibrand factor. In conclusions, HO-1 gene promoter polymorphisms were associated with AF recurrence after catheter ablation.
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DOI：
10.1111/j.1540-8167.2008.01393.x
发表时间：
2009-06-01
影响因子：
2.7
作者：
Lin, Yenn-Jiang;Tai, Ching-Tai;Chen, Shin-Ann
通讯作者：
Chen, Shin-Ann
DOI：
10.1161/atvbaha.107.142638
发表时间：
2007-06-01
影响因子：
8.7
作者：
Kroenke, Gerhard;Kadl, Alexandra;Leitinger, Norbert
通讯作者：
Leitinger, Norbert
影响因子：
37.8
作者：
Melo, LG;Agrawal, R;Dzau, VJ
通讯作者：
Dzau, VJ
影响因子：
5.8
作者：
Immenschuh, S;Ramadori, G
通讯作者：
Ramadori, G
影响因子：
2.8
作者：
Lin, Yenn-Jiang;Tsao, Hsuan-Ming;Chen, Shih-Ann
通讯作者：
Chen, Shih-Ann