Genetic Network Analyzer: A Tool for the Qualitative Modeling and Simulation of Bacterial Regulatory Networks
Genetic Network Analyzer: A Tool for the Qualitative Modeling and Simulation of Bacterial Regulatory Networks
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DOI：
10.1007/978-1-61779-361-5_22
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Ropers, Delphine
中科院分区：
文献类型：
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作者：
Batt, Gregory;Besson, Bruno;Ropers, Delphine
遗传网络分析器 (GNA) 是一种基于所谓的分段线性微分方程模型的基因调控网络定性建模和模拟工具。我们描述了该工具在细菌调节网络建模的背景下的使用，特别是控制大肠杆菌适应碳饥饿条件的全球调节器网络。我们展示了建模者如何通过 GNA 定义监管网络、构建网络模型、确定系统的稳态、对网络动态进行定性模拟，并使用模型检查工具分析模拟结果。这个例子说明了定性方法对细菌调节网络动态分析的兴趣。
Genetic Network Analyzer (GNA) is a tool for the qualitative modeling and simulation of gene regulatory networks, based on so-called piecewise-linear differential equation models. We describe the use of this tool in the context of the modeling of bacterial regulatory networks, notably the network of global regulators controlling the adaptation of Escherichia coli to carbon starvation conditions. We show how the modeler, by means of GNA, can define a regulatory network, build a model of the network, determine the steady states of the system, perform a qualitative simulation of the network dynamics, and analyze the simulation results using model-checking tools. The example illustrates the interest of qualitative approaches for the analysis of the dynamics of bacterial regulatory networks.