LYL-1, A NOVEL GENE ALTERED BY CHROMOSOMAL TRANSLOCATION IN T-CELL LEUKEMIA, CODES FOR A PROTEIN WITH A HELIX-LOOP-HELIX DNA-BINDING MOTIF
LYL-1, A NOVEL GENE ALTERED BY CHROMOSOMAL TRANSLOCATION IN T-CELL LEUKEMIA, CODES FOR A PROTEIN WITH A HELIX-LOOP-HELIX DNA-BINDING MOTIF
复制标题
DOI：
10.1016/0092-8674(89)90404-2
复制
发表时间：
1989-07-14
期刊：
影响因子：
64.5
通讯作者：
CLEARY, ML
中科院分区：
文献类型：
--
作者：
MELLENTIN, JD;SMITH, SD;CLEARY, ML
我们在T细胞急性淋巴细胞白血病的染色体易位断点处鉴定了染色体带19p13上的一个易位单元。lyl-1基因在t（7;19）易位后发生结构改变，导致其与t细胞受体c . β头对头并置。基因和lyl-1 RNA的截断。预测的lyl-1基因的蛋白产物包含一个潜在的螺旋-环-螺旋DNA结合基元，该基元也存在于一些参与细胞增殖和分化控制的蛋白中：Myc家族的所有成员，MyoD1, myogenin, Drosophila ahaete - sccute， twist和daughter - less蛋白，以及最近描述的两种免疫球蛋白增强子结合蛋白。Lyl-1在细胞转化中的作用表明，其他含有类似DNA结合基序的蛋白质也可能参与各种细胞系的肿瘤转化。
We have characterized a transciption unit at chromosome band 19p13 that lies at the site of a chromosomal translocation breakpoint in T cell acute lymphoblastic leukemia. The lyl-1 gene is structurally altered following a t(7;19) translocation, resulting in its head-to-head juxtaposition with the T cell receptor C.beta. gene and truncation of lyl-1 RNA. The predicted protein product of the lyl-1 gene contains a potential helix-loop-helix DNA binding motif also found in several protein involved in the control of cellular proliferation and differentiation: all members of the Myc family, MyoD1, myogenin, the Drosophila achaete-scute, twist, and daughterless proteins, and two recently described immunoglobulin enhancer binding proteins. The implication of Lyl-1 in cellular transformation suggests that other proteins containing similar DNA binding motifs may also be involved with neoplastic transformation in various cellular lineages.