HISTOLOGIC GRADING OF ADENOID CYSTIC CARCINOMA OF THE SALIVARY-GLANDS
HISTOLOGIC GRADING OF ADENOID CYSTIC CARCINOMA OF THE SALIVARY-GLANDS
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DOI：
10.1002/1097-0142(19840915)54:6
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发表时间：
1984-01-01
期刊：
影响因子：
6.2
通讯作者：
WHITE, RA
中科院分区：
文献类型：
--
作者：
SZANTO, PA;LUNA, MA;WHITE, RA
对79例涎腺腺样囊性癌进行了研究，以确定肿瘤形态学特征与预后之间是否存在相关性。建立了三个组织学等级：I级，肿瘤具有管状和筛状区域，但没有实体成分; II级，筛状肿瘤是纯的或混合有< 30%的实体区域;和III级，肿瘤以实体模式为主。15年累积生存率分别为39%，26%和5%，I级，II级和III级，分别。III级肿瘤较大，复发频繁，4年内死亡。I级病变较小，适合完全手术切除，临床病程延长。II级肿瘤在临床和病理上均介于其他2种类型之间。腺样囊性癌的其他重要预后特征是其原发部位、手术切缘有无和累及的解剖结构。
Patients (79) with adenoid cystic carcinoma arising in salivary glands were studied to determine whether a correlation existed between the morphologic features of the tumor and the prognosis. Three histologic grades were established: Grade I, tumors with tubular and cribriform areas but without solid components; Grade II, cribriform tumors that were either pure or mixed with < 30% of solid areas; and Grade III, tumors with a predominantly solid pattern. Cumulative survival rates at 15 yr were 39%, 26% and 5%, for Grades I, II and III, respectively. Grade III tumors were larger, recurred frequently and killed the patients within 4 yr. Grade I lesions were smaller, were amenable to complete surgical excision and had a protracted clinical course. Grade II tumors lay between the other 2 forms both clinically and pathologically. Other important prognostic features of the adenoid cystic carcinoma were its primary site, its presence or absence at surgical margins and the anatomic structures it involved.