SIALIC-ACID - EFFECT OF REMOVAL ON CALCIUM EXCHANGEABILITY OF CULTURED HEART-CELLS
SIALIC-ACID - EFFECT OF REMOVAL ON CALCIUM EXCHANGEABILITY OF CULTURED HEART-CELLS
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DOI：
10.1126/science.948758
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发表时间：
1976-01-01
期刊：
影响因子：
56.9
通讯作者：
SERAYDARIAN, K
中科院分区：
文献类型：
--
作者：
LANGER, GA;FRANK, JS;SERAYDARIAN, K
用纯化的神经氨酸酶从培养的心脏细胞[新生大鼠]中特异性去除唾液酸增加细胞钙交换。钾交换不受影响或略有下降。唾液酸的去除也允许La，通常限于细胞表面，进入细胞和取代超过80%的细胞Ca。一个特定的作用，细胞表面成分的控制中的钙交换在心脏中表示。
Specific removal of sialic acid from cultured heart cells [newborn rat] with purified neuraminidase increases cellular Ca exchangeability. K exchange is unaffected or slightly decreased. Sialic acid removal also permits La, normally restricted to the cellular surface, to enter the cells and displace more than 80% of cellular Ca. A specific role of cellular surface components in the control of Ca exchangeability in the heart is indicated.