The cardiovascular risk of young women with polycystic ovary syndrome:: An observational, analytical, prospective case-control study
The cardiovascular risk of young women with polycystic ovary syndrome:: An observational, analytical, prospective case-control study
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DOI：
10.1210/jc.2003-032049
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发表时间：
2004-08-01
影响因子：
5.8
通讯作者：
Colao, A
中科院分区：
文献类型：
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作者：
Orio, F;Palomba, S;Colao, A
为了评估多囊卵巢综合征（PCOS）的心血管风险，我们调查了30名年轻PCOS女性和30名年龄和体重指数（BMI）匹配的健康女性的血脂谱、代谢模式和超声心动图。PCOS组空腹血糖、胰岛素水平、胰岛素敏感性稳态模型评分、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）水平、TC/高密度脂蛋白胆固醇（HDL-C）比值均高于对照组，而HDL-C水平低于对照组。此外，PCOS妇女的左心房大小（32.0 +/- 4.9 vs. 27.4 +/- 2.1 mm; P < 0.0001）和左心室质量指数（80.5 ± 18.1 vs. 56.1 ± 5.4 g/m2; P < 0.0001）和左心室射血分数降低（64.4 +/- 4.1 vs. 67.1 +/- 2.6%; P = 0.003）和早期与晚期二尖瓣血流速度比（1.6 +/- 0.4 vs. 2.1 +/- 0.2; P < 0.0001）。当患者和对照组根据BMI [正常体重（BMI，> 18和< 25 kg/m2），超重（BMI，25.1-30 kg/m2），和肥胖（BMI，> 30 kg/m2）]分组时，PCOS妇女和对照组之间的差异在超重和肥胖妇女中保持不变。在正常体重的PCOS妇女中，观察到左心室质量指数显著增加和舒张期充盈减少，尽管与对照组相比，TC，LDL-C，HDL-C，TC/HDL-C比值和TG没有变化。总之，我们的数据显示，即使在无心脏病症状的年轻女性中，PCOS对心血管系统也有不利影响。
To evaluate the cardiovascular risk of polycystic ovary syndrome ( PCOS), we investigated lipid profile, metabolic pattern, and echocardiography in 30 young women with PCOS and 30 healthy age- and body mass index (BMI)-matched women. PCOS women had higher fasting glucose and insulin levels, homeostasis model assessment score of insulin sensitivity, total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels, and TC/high density lipoprotein cholesterol (HDL-C) ratio and lower HDL-C levels than controls. Additionally, PCOS women had higher left atrium size (32.0 +/- 4.9 vs. 27.4 +/- 2.1 mm; P < 0.0001) and left ventricular mass index (80.5 +/- 18.1 vs. 56.1 +/- 5.4 g/m(2); P < 0.0001) and lower left ventricular ejection fraction (64.4 +/- 4.1 vs. 67.1 +/- 2.6%; P = 0.003) and early to late mitral flow velocity ratio (1.6 +/- 0.4 vs. 2.1 +/- 0.2; P < 0.0001) than controls. When patients and controls were grouped according to BMI [normal weight (BMI,> 18 and < 25 kg/m(2)), overweight (BMI, 25.1-30 kg/m(2)), and obese (BMI, > 30 kg/m(2))], the differences between PCOS women and controls were maintained in overweight and obese women. In normal weight PCOS women, a significant increase in left ventricular mass index and a decrease in diastolic filling were observed, notwithstanding no change in TC, LDL-C, HDL-C, TC/HDL-C ratio, and TG compared with controls. In conclusion, our data show the detrimental effect of PCOS on the cardiovascular system even in young women asymptomatic for cardiac disease.