Association of prenatal exposure to acetaminophen and coffee with childhood asthma
Association of prenatal exposure to acetaminophen and coffee with childhood asthma
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DOI：
10.1002/pds.3940
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发表时间：
2016-02-01
影响因子：
2.6
通讯作者：
Li, Jiong
中科院分区：
文献类型：
--
作者：
Liu, Xiaoqin;Liew, Zeyan;Li, Jiong
研究目的一些研究表明母亲在怀孕期间使用对乙酰氨基酚与后代的哮喘有关，咖啡的摄入可能会改变对乙酰氨基酚的毒性。我们的目的是研究是否怀孕母亲对乙酰氨基酚的使用会增加后代哮喘的风险，以及这种潜在的关联是否可以修改由产妇coffee consumption.MethodsWe包括63652活产单胎登记在丹麦国家出生队列。母亲对乙酰氨基酚的使用和咖啡消费在怀孕期间进行了前瞻性评估，通过登记问卷和三个计算机辅助电话访谈。通过丹麦国家患者登记处和丹麦国家处方登记处确定哮喘病例。我们估计的风险比（HR）为哮喘根据产前对乙酰氨基酚和咖啡暴露使用考克斯比例风险回归model.ResultsAfter调整潜在的混杂因素，对乙酰氨基酚在怀孕期间使用与后代哮喘的风险增加（HR=1.16，95%置信区间（CI）：1.11-1.22）。怀孕期间喝咖啡与风险略有降低相关（HR=0.94，95%CI：0.90-0.99）。但是，没有强有力的证据表明，对乙酰氨基酚的使用对后代哮喘的咖啡consumptionsConclusionsAcetaminophen在怀孕期间使用与后代哮喘，这是不修改咖啡消费量的风险适度增加。版权所有（c）2015约翰威利父子有限公司
PurposeSome studies have suggested that maternal acetaminophen use during pregnancy is associated with asthma in the offspring, and coffee consumption may modify the toxicity of acetaminophen. We aim to examine whether pregnancy maternal acetaminophen use increases the risk for offspring asthma, and whether such a potential association could be modified by maternal coffee consumption.MethodsWe included 63652 live-born singletons enrolled in the Danish National Birth Cohort. Maternal acetaminophen use and coffee consumption during pregnancy were assessed prospectively via the enrolment questionnaire and three computer-assisted telephone interviews. Asthma cases were identified by using the Danish National Patient Register and the Danish National Prescription Registry. We estimated the hazard ratios (HRs) for asthma according to prenatal acetaminophen and coffee exposure using Cox proportional hazards regression model.ResultsAfter adjusting for potential confounders, acetaminophen use during pregnancy was associated with an increased risk of offspring asthma (HR=1.16, 95% confidence interval (CI): 1.11-1.22). Coffee drinking during pregnancy was associated with a slightly decreased risk (HR=0.94, 95%CI: 0.90-0.99). But there was no strong evidence of effect measure modification of acetaminophen use on offspring asthma by coffee consumption.ConclusionsAcetaminophen use during pregnancy was associated with a modest increased risk for offspring asthma, which was not modified by coffee consumption. Copyright (c) 2015 John Wiley & Sons, Ltd.