Mitochondrial fusion and division: Regulation and role in cell viability.

Mitochondrial fusion and division: Regulation and role in cell viability.
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DOI:
10.1016/j.semcdb.2008.12.012
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发表时间:
2009-05
影响因子:
7.3
通讯作者:
Karbowski M
Karbowski M
中科院分区:
生物学2区
文献类型:
--
作者:
Benard G;Karbowski M

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在过去的十年中,线粒体研究取得了一些最令人兴奋的突破,其中包括各种分子成分的发现,这些分子成分调节着细胞中线粒体的动力学和组织,以及线粒体融合和分裂在维持细胞稳态中的作用。本文就线粒体融合和分裂机制的调控作一综述。讨论了新发现的与mitofusin/ opa1依赖性线粒体融合和drp1依赖性线粒体分裂相关的因素。此外,对线粒体融合和分裂在维持细胞功能中的作用的最新发现也进行了详细的综述。
Discovery of various molecular components regulating dynamics and organization of the mitochondria in cells, together with novel insights into the role of mitochondrial fusion and division in the maintenance of cellular homeostasis, have provided some of the most exciting breakthroughs in the last decade of mitochondrial research. The focus of this review is on the regulation of mitochondrial fusion and division machineries. The newly identified factors associated with mitofusin/OPA1-dependent mitochondrial fusion, and Drp1-dependent mitochondrial division are discussed. Furthermore, the most recent findings on the role of mitochondrial fusion and division in the maintenance of cell function are also reviewed here in some detail.
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