No Evidence that Extended Tracts of Homozygosity are Associated with Alzheimer's Disease
No Evidence that Extended Tracts of Homozygosity are Associated with Alzheimer's Disease
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DOI：
10.1002/ajmg.b.31216
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发表时间：
2011-12-01
影响因子：
2.8
通讯作者：
Williams, Julie
中科院分区：
文献类型：
--
作者：
Sims, Rebecca;Dwyer, Sarah;Williams, Julie
我们试图在1,955例阿尔茨海默病病例和955例老年人筛选对照的全基因组关联数据集中调查纯合性扩展运行的贡献，这些老年人筛选对照基因分型为529,205个常染色体单核苷酸多态性。纯合性的片段可能标志着从共同祖先遗传的区域，如果在病例中比对照组更频繁地观察到，则可能反映疾病位点。我们发现，与对照组相比，阿尔茨海默病病例中没有过多的纯合束，也没有个体的纯合性表现出与阿尔茨海默病的关联。(C)2011 Wiley-Liss，Inc.
We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease. (C) 2011 Wiley-Liss, Inc.