Inhibitory effect of resveratrol on proteinuria, hypoalbuminemia and hyperlipidemia in nephritic rats
Inhibitory effect of resveratrol on proteinuria, hypoalbuminemia and hyperlipidemia in nephritic rats
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DOI：
10.1016/s0024-3205(01)01061-x
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发表时间：
2001-05-11
期刊：
影响因子：
6.1
通讯作者：
Yagasaki, K
中科院分区：
文献类型：
--
作者：
Nihei, T;Miura, Y;Yagasaki, K
白藜芦醇是一种存在于葡萄和其他植物中的多酚化合物，在肾小球肾炎大鼠中研究了对蛋白尿、低白蛋白血症和高脂血症的影响。通过静脉注射抗大鼠肾小球基底膜兔抗血清诱发肾炎。肾病大鼠经口插管给予白藜芦醇（5 mg/天/100 g体重）14天，而对照肾病大鼠以及正常大鼠同样仅给予载体。通过白藜芦醇治疗，由于肾炎诱导引起的肝脏和肾脏的增大显著减少，同时部分恢复肾炎诱导的体重增加减少。蛋白尿和低白蛋白血症，肾病综合征的特征性症状，显着补救，即尿蛋白排泄抑制和血清白蛋白浓度增加白藜芦醇治疗。白藜芦醇还能显著抑制肾炎引起的高脂血症，其降血脂作用比降胆固醇作用更为显著。从这些结果，白藜芦醇是一个有效的抗肾小球肾炎的食物因子，能够抑制蛋白尿，低白蛋白血症和高脂血症在同一时间。(C)2001 Elsevier Science Inc.保留所有权利。
The effect of resveratrol, a polyphenolic compound present in grapes and other plants, on proteinuria, hypoalbuminemia and hyperlipidemia was studied in rats with glomerulonephritis. The nephritis was induced by an intravenous injection of anti-rat kidney glomerular basement membrane rabbit antiserum. Nephritic rats were given oral intubation of resveratrol (5 mg/day/100g body weight) for 14 days, while control nephritic rats as well as normal ones were similarly given vehicle alone. By resveratrol treatment, enlargement in liver and kidney due to nephritis induction was significantly reduced, together with partial restoration of nephritis-induced reduction in body weight gain. Both proteinuria and hypoalbuminemia, characteristic symptoms to nephrotic syndrome, were significantly remedied, that is, urinary protein excretion was suppressed and serum albumin concentration was increased by resveratrol treatment. Resveratrol also suppressed significantly hyperlipidemia incident to nephritis, the hypotriglyceridemic action being more prominent than the hypocholesterolemic one. From these results, resveratrol is suggested to be a potent anti-glomerulonephritic food factor capable of suppressing proteinuria, hypoalbuminemia and hyperlipidemia at the same time. (C) 2001 Elsevier Science Inc. Ail rights reserved.