The relationship between plasma taurine and other amino acid levels in human sepsis
The relationship between plasma taurine and other amino acid levels in human sepsis
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DOI：
10.1093/jn/130.9.2222
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发表时间：
2000-09-01
影响因子：
4.2
通讯作者：
Castagneto, M
中科院分区：
文献类型：
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作者：
Chiarla, C;Giovannini, I;Castagneto, M
虽然有关于创伤、脓毒症和危重病患者血浆牛磺酸水平降低的报道，但对血浆牛磺酸、其他氨基酸水平和代谢变量之间的关系知之甚少。我们分析了一个大系列的血浆氨基酸谱获得创伤脓毒症患者谁接受全肠外营养。通过回归分析评估血浆牛磺酸、其他氨基酸水平、胃肠外底物剂量与代谢和心肺变量之间的相关性。创伤后低牛磺酸血症，其次是部分恢复到较低的异常值时，脓毒症的发展。牛磺酸水平与谷氨酸、天冬氨酸、β-丙氨酸和磷酸乙醇胺水平直接显著相关（与其他氨基酸无关）。这些氨基酸的水平随着全胃肠外营养中亮氨酸、异亮氨酸和缬氨酸剂量的增加而同时增加。牛磺酸的减少与乳酸盐、动静脉O-2浓度差和呼吸指数的增加有关，与胆固醇和心脏指数的降低有关。这些结果表征了脓毒症中血浆牛磺酸和其他氨基酸水平之间的关系，提供了可能支持牛磺酸可用性的氨基酸相互作用的证据，并显示随着代谢和心肺模式的恶化，血浆牛磺酸更严重地降低。
Although reports of decreased plasma taurine in trauma, sepsis and critical illness are available, very little is known about the relationships among changes in plasma taurine, other amino acid levels and metabolic variables. We analyzed a large series of plasma amino acid profiles obtained in trauma patients with sepsis who were undergoing total parenteral nutrition. The correlations between plasma taurine, other amino acid levels, parenteral substrate doses and metabolic and cardiorespiratory variables were assessed by regression analysis. Post-traumatic hypotaurinemia was followed by partial recovery toward less abnormal values when sepsis developed. Levels of taurine were directly and significantly related to levels of glutamate, aspartate, beta-alanine and phosphoethanolamine (and unrelated to other amino acids). Levels of these amino acids increased simultaneously with increasing doses of leucine, isoleucine and valine in total parenteral nutrition. Decreasing taurine was associated with increasing lactate, arteriovenous O-2 concentration difference and respiratory index, and with decreasing cholesterol and cardiac index. These results characterize the relationships between plasma taurine and other amino acid levels in sepsis, provide evidence of amino acid interactions that may support taurine availability and show more severe decreases in plasma taurine with the worsening of metabolic and cardiorespiratory patterns.