Simulation and experimental study on the influence of needle-free jet injection nozzle structure on injection performance
Simulation and experimental study on the influence of needle-free jet injection nozzle structure on injection performance
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DOI：
10.1016/j.jddst.2021.103043
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发表时间：
2022-02-01
影响因子：
5
通讯作者：
Zhang, Yong
中科院分区：
文献类型：
--
作者：
Wang, Zhizhi;Song, Dongxiao;Zhang, Yong
无针喷射注射是传统注射的绝佳替代方式，可以减少患者对针头和针头伤害的恐惧，降低交叉污染的概率。它非常适合小剂量药物的给药，如疫苗和胰岛素。无针射流喷嘴的结构决定了射流的特性，优化后的喷嘴结构可以改善无针射流的喷射性能。采用可实现的k-ε湍流模型研究了不同喷嘴锥角和喷嘴长度对喷射效果的影响。峰值滞止压力、射流速度和峰值湍流强度被选为主要的研究参数。通过进一步分析得到了较优的喷嘴结构，并通过实验验证了仿真模型的准确性。结果表明，在5种不同锥度的喷嘴中，在一定锥度范围内，锥度越小的喷嘴，其射流速度越高，喷嘴出口处的峰值滞止压力也越大。相反，具有较小锥度的喷嘴在距离喷嘴孔口4mm处具有较低的射流速度。喷管长度对驻点压力峰值的影响有限，没有明显的规律性，而对湍流强度的影响比较明显。喷嘴长度越长，湍流强度越小。同时，还研究了不同粘度的液体和不同弹性系数的驱动弹簧对喷射性能的影响。进行了射流冲击力实验。结果表明，模拟结果与实验结果高度一致，验证了CFD模型的准确性。研究结果为优化商用无针喷射注射器的喷嘴结构提供了思路，有助于实现高效给药。
Needle-free jet injection is an excellent alternative to conventional injection, which can reduce patients' fear of needle and needle injury and reduce the probability of cross contamination. It is highly appropriate for the administration of small doses of medicines, such as vaccines and insulin. The structure of the needle-free jet injector nozzle determines the properties of the jet, and the optimized nozzle can improve injection performance. This study used the realizable k-epsilon turbulence model to study the effects of different nozzle cone angles and nozzle lengths on the injection effect. The peak stagnation pressure, jet velocity, and peak turbulence intensity were selected as the primary research parameters. We achieved a better nozzle structure with further analysis, and experiments were performed to verify the accuracy of the simulation model. The simulation results show that in the five nozzles with different taper settings, the nozzle with a smaller taper has higher jet velocity and peak stagnation pressure at the nozzle orifice and within a specific taper range. On the contrary, the nozzle with a smaller taper has a lower jet velocity at 4 mm away from the nozzle orifice. The effect of the nozzle length on peak stagnation pressure is limited and shows no apparent law, while the effect on the turbulence intensity is evident. The longer the nozzle length is, the less turbulence intensity is. At the same time, we also studied the influence of different viscosity liquids and different elastic coefficients of the driving spring on the injection performance. The jet impact force experiment was carried out. The results show that the simulation results are highly consistent with the experimental results, which verify the accuracy of the CFD model. The results provide ideas for optimizing the nozzle structure of commercial needle-free jet injector and help realize efficient drug delivery.