Linking Novelty Seeking and Harm Avoidance Personality Traits to Cerebellar Volumes
Linking Novelty Seeking and Harm Avoidance Personality Traits to Cerebellar Volumes
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DOI：
10.1002/hbm.22174
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发表时间：
2014-01-01
影响因子：
4.8
通讯作者：
Spalletta, Gianfranco
中科院分区：
文献类型：
--
作者：
Laricchiuta, Daniela;Petrosini, Laura;Spalletta, Gianfranco
人格特质是包括认知、情感和行为特征的多维特质，并且广泛的大脑结构介导个体差异。人格特质的差异与特定脑区的脑形态测量学相关，神经影像学研究显示人格障碍受试者小脑的结构或功能异常，表明小脑在情感处理中的作用和对人格特征的影响。为了检验小脑[白色物质（WM）和皮质]体积与Cloninger气质和性格量表（TCI）的四个气质量表得分相关的假设，共有125名年龄在18-67岁的健康受试者（男性= 52）完成了TCI并接受了磁共振成像。线性回归分析显示，各气质量表得分分别与小脑WM体积和左右半球皮质体积相关。与我们的假设一致，新奇寻求（NS）分数与WM和小脑皮质体积呈正相关。伤害避免（HA）评分与WM和小脑皮质体积呈负相关。NS和HA评分的个体差异范围反映了小脑体积的变异范围。目前的数据表明，某些人格特质的小脑基底将人格与大脑区域之间的关系扩展到一个迄今为止被认为主要涉及运动和认知功能的结构，更少涉及情感过程，甚至更少涉及人格个体差异。《脑地图》35：285-296，2014年。(c)2012 Wiley Periodicals，Inc.
Personality traits are multidimensional traits comprising cognitive, emotional, and behavioral characteristics, and a wide array of cerebral structures mediate individual variability. Differences in personality traits covary with brain morphometry in specific brain regions, and neuroimaging studies showed structural or functional abnormalities of cerebellum in subjects with personality disorders, suggesting a cerebellar role in affective processing and an effect on personality characteristics. To test the hypothesis that cerebellar [white matter (WM) and cortex] volumes are correlated with scores obtained in the four temperamental scales of the Temperament and Character Inventory (TCI) by Cloninger, a total of 125 healthy participants aged 18-67 years of both genders (males = 52) completed the TCI and underwent magnetic resonance imaging. The scores obtained in each temperamental scale were associated with the volumes of cerebellar WM and cortex of right and left hemispheres separately by using linear regression analyses. In line with our hypothesis, novelty seeking (NS) scores were positively associated with WM and cortex cerebellar volumes. Harm avoidance (HA) scores were negatively associated with WM and cortex cerebellar volumes. The range of individual differences in NS and HA scores reflects the range of variances of cerebellar volumes. The present data indicating a cerebellar substrate for some personality traits extend the relationship between personality and brain areas to a structure up to now thought to be involved mainly in motor and cognitive functions, much less in emotional processes and even less in personality individual differences. Hum Brain Mapp 35:285-296, 2014. (c) 2012 Wiley Periodicals, Inc.