Impact of formulation and operating parameters on particle size and grinding media wear in wet media milling of organic compounds - A case study for pyrene
Impact of formulation and operating parameters on particle size and grinding media wear in wet media milling of organic compounds - A case study for pyrene
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DOI：
10.1016/j.apt.2016.09.026
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发表时间：
2016-11-01
影响因子：
5.2
通讯作者：
Kwade, A.
中科院分区：
文献类型：
--
作者：
Flach, F.;Konnerth, C.;Kwade, A.
本文研究了结晶有机模型化合物芘的细磨工艺和配方参数的影响。通过在水中的湿介质研磨产生亚微米颗粒。通过应用电空间稳定和优化的工艺参数，获得小于100 nm的颗粒尺寸。此外，还研究了配方和工艺参数对研磨介质磨损的影响。具有离子表面活性剂和非离子聚合物的产品配方被确定为减少研磨磨损的重要参数。此外，操作参数的设置以及研磨介质材料的选择被认为是减少产品污染的关键参数。研磨介质磨损与比能输入成正比，可以通过优化研磨介质的应力能来最小化。(C)2016年日本粉末技术学会。由Elsevier B.V.和日本粉末技术协会出版。All rights reserved.
This study presents the influence of process and formulation parameters on fine grinding of the crystalline organic model compound pyrene. Submicron particles were produced by wet media milling in water. By applying an electrosteric stabilization and optimized process parameters, particle sizes below 100 nm were obtained. Additionally, the influence of formulation and process parameters on grinding media wear were investigated. The product formulation with an ionic surfactant and a nonionic polymer was identified as a significant parameter to reduce the grinding wear. Furthermore, the set of operating parameters as well as the choice of grinding media material were found as key parameters to reduce product contamination. Grinding media wear is proportional to the specific energy input and can be minimized by optimizing the stress energy of grinding media. (C) 2016 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.