Bayesian Phylodynamic Analysis Reveals the Dispersal Patterns of African Swine Fever Virus.
Bayesian Phylodynamic Analysis Reveals the Dispersal Patterns of African Swine Fever Virus.
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DOI：
10.3390/v14050889
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发表时间：
2022-04-25
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非洲猪瘟病毒（ASFV）的进化和人口统计学历史对制定有效和可持续的管理战略具有潜在的相当价值。在这项研究中，我们基于从NCBI获得的ASFV全基因组、B646L基因和E183L基因序列，对世界范围内的ASFV进行了系统发育、系统动力学和系统地理分析，以了解ASFV的流行病学。贝叶斯系统动力学分析和系统发育分析表明，E183L与全基因组的聚类结果高度相似。贝叶斯系统动力学分析也揭示了非洲猪瘟的迁移证据和人口统计学历史。进化速率估计为1.14 × 10−5个替换/位点/年。南非病毒人群的大量外移在病毒在世界范围内传播方面发挥了关键作用。我们的研究不仅为更好地利用基因组数据提供了资源，而且通过近70年的宽采样窗口揭示了非洲猪瘟在全球范围内的全面进化历史。阐明了病毒的时空传播特征，这对制定控制病毒的策略具有重要意义。
The evolutionary and demographic history of African swine fever virus (ASFV) is potentially quite valuable for developing efficient and sustainable management strategies. In this study, we performed phylogenetic, phylodynamic, and phylogeographic analyses of worldwide ASFV based on complete ASFV genomes, B646L gene, and E183L gene sequences obtained from NCBI to understand the epidemiology of ASFV. Bayesian phylodynamic analysis and phylogenetic analysis showed highly similar results of group clustering between E183L and the complete genome. The evidence of migration and the demographic history of ASFV were also revealed by the Bayesian phylodynamic analysis. The evolutionary rate was estimated to be 1.14 × 10−5 substitution/site/year. The large out-migration from the viral population in South Africa played a crucial role in spreading the virus worldwide. Our study not only provides resources for the better utilization of genomic data but also reveals the comprehensive worldwide evolutionary history of ASFV with a broad sampling window across ~70 years. The characteristics of the virus spatiotemporal transmission are also elucidated, which could be of great importance for devising strategies to control the virus.