2 CORONAVIRUSES ISOLATED FROM CENTRAL NERVOUS-SYSTEM TISSUE OF 2 MULTIPLE-SCLEROSIS PATIENTS
2 CORONAVIRUSES ISOLATED FROM CENTRAL NERVOUS-SYSTEM TISSUE OF 2 MULTIPLE-SCLEROSIS PATIENTS
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DOI：
10.1126/science.7403860
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发表时间：
1980-01-01
期刊：
影响因子：
56.9
通讯作者：
GERDES, JC
中科院分区：
文献类型：
--
作者：
BURKS, JS;DEVALD, BL;GERDES, JC
从两名多发性硬化症患者的尸检脑组织中分离到两种冠状病毒。这些病毒被这些患者的血清和脊髓液中和。尽管大多数人群对这些病毒分离株都有抗体，但多发性硬化症患者的血清抗体浓度略高于对照组。这些结果表明，冠状病毒应被视为一种额外的病毒，在多发性硬化症的病因学中具有潜在的意义。
Two coronaviruses were isolated from brain material obtained at autopsy from two multiple sclerosis patients. The viruses were neutralized by serum and spinal fluid from these patients. Although most of the population have antibody to these virus isolates, multiple sclerosis patients have slightly higher concentrations of serum antibody than controls. The results suggest that coronaviruses should be considered as one additional virus with a potential implication in the etiology of multiple sclerosis.