High-speed microfluidic differential manometer for cellular-scale hydrodynamics
High-speed microfluidic differential manometer for cellular-scale hydrodynamics
复制标题
DOI：
10.1073/pnas.0507171102
复制
发表时间：
2006-01-17
影响因子：
11.1
通讯作者：
Stone, HA
中科院分区：
文献类型：
--
作者：
Abkarian, M;Faivre, M;Stone, HA
我们提出了一种广泛适用的高速微流体方法，用于测量沿微米尺寸通道的动态压降变化，并通过对单个流动细胞规模产生的额外压降的测量来说明该技术的潜力。显示了药物修饰的细胞膜机械性能的影响。最后，在流动过程中的单个溶血事件与膜破裂的临界压降同时记录。这种与尺度无关的测量方法可以应用于任何改变微通道或纳米通道的流体动力学阻力的动态过程或事件。
We propose a broadly applicable high-speed microfluiclic approach for measuring dynamical pressure-drop variations along a micrometer-sized channel and illustrate the potential of the technique by presenting measurements of the additional pressure drop produced at the scale of individual flowing cells. The influence of drug-modified mechanical properties of the cell membrane is shown. Finally, single hemolysis events during flow are recorded simultaneously with the critical pressure drop for the rupture of the membrane. This scale-independent measurement approach can be applied to any dynamical process or event that changes the hydrodynamic resistance of micro- or nanochannels.