Auditory evoked brain potentials as markers of chronic effects of mild traumatic brain injury in mid-life.
Auditory evoked brain potentials as markers of chronic effects of mild traumatic brain injury in mid-life.
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听觉诱发的大脑电位是中年轻度创伤性脑损伤慢性影响的标志。
DOI：
10.1016/j.clinph.2021.09.007
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Walker,WilliamC
中科院分区：
文献类型：
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作者：
ManningFranke,Laura;Perera,RobertA;Aygemang,AmmaA;Marquardt,CraigA;Teich,Collin;Sponheim,ScottR;Duncan,ConnieC;Walker,WilliamC
听觉事件相关电位（ERP）与老年痴呆前期的相关性也可能对中年轻度创伤性脑损伤（mTBI）的慢性效应敏感。除了mTBI病史，其他临床因素也可能影响脑功能的ERP测量。本研究的目的是评估mTBI的历史，听觉ERP指标，和常见的comorbidity. MethodsERP引起的听觉目标检测任务，心理症状，听力灵敏度之间的关系收集在152战斗暴露的退伍军人和服务成员，作为前瞻性观察队列研究的一部分。参与者平均年龄为43.6岁，根据阳性（n = 110）或阴性（n = 42）mTBI病史进行分组。阳性病史分为重复mTBI（3 +）（n = 40）和非重复mTBI（1-2）（n = 70）。与非重复性和无mTBI的参与者相比，重复性mTBI的参与者对非靶点的P50更大，对非靶点和靶点的N100更小。N200的变化介导的抑郁症和焦虑症状和听力损失，没有证据的补充直接mTBI pathway.ConclusionsAuditory brain function different between the positive and negative mTBI groups，特别是重复性损伤，这涉及更多的基本，早期听觉处理比任何mTBI曝光。内在化的精神病理学（抑郁和焦虑）和听力损失的症状与mTBI对行为相关的和新颖的刺激的减少的大脑反应有关。SignificanceA由mTBI，特别是重复mTBI赋予的中年神经脆弱性，可以使用听觉脑电位检测，因此听觉ERP是该人群中痴呆风险研究的目标。
ObjectiveAuditory event-related potential (ERP) correlates of pre-dementia in late-life may also be sensitive to chronic effects of mild traumatic brain injury (mTBI) in mid-life. In addition to mTBI history, other clinical factors may also influence ERP measures of brain function. This study’s objective was to evaluate the relationship between mTBI history, auditory ERP metrics, and common comorbidities.MethodsERPs elicited during an auditory target detection task, psychological symptoms, and hearing sensitivity were collected in 152 combat-exposed veterans and service members, as part of a prospective observational cohort study. Participants, with an average age of 43.6 years, were grouped according to positive (n = 110) or negative (n = 42) mTBI history. Positive histories were subcategorized into repetitive mTBI (3 + ) (n = 40) or non-repetitive (1–2) (n = 70).ResultsPositive history of mTBI was associated with reduced N200 amplitude to targets and novel distractors. In participants with repetitive mTBI compared to non-repetitive and no mTBI, P50 was larger in response to nontargets and N100 was smaller in response to nontargets and targets. Changes in N200 were mediated by depression and anxiety symptoms and hearing loss, with no evidence of a supplementary direct mTBI pathway.ConclusionsAuditory brain function differed between the positive and negative mTBI groups, especially for repetitive injury, which implicated more basic, early auditory processing than did any mTBI exposure. Symptoms of internalizing psychopathology (depression and anxiety) and hearing loss are implicated in mTBI’s diminished brain responses to behaviorally relevant and novel stimuli.SignificanceA mid-life neurologic vulnerability conferred by mTBI, particularly repetitive mTBI, may be detectable using auditory brain potentials, and so auditory ERPs are a target for study of dementia risk in this population.