The Effects of Flavonoids on Bone
The Effects of Flavonoids on Bone
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DOI：
10.1007/s11914-014-0212-5
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发表时间：
2014-06-01
影响因子：
4.3
通讯作者：
Hardcastle, Antonia C.
中科院分区：
文献类型：
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作者：
Welch, Ailsa A.;Hardcastle, Antonia C.
骨质疏松症和脆性骨折是我们老龄化人口中日益严重的问题，大约每2名女性中就有1名，每5名男性中就有1名在其一生中患有骨质疏松性骨折。虽然有既定的因素可以降低骨折的风险，如保持体力活动，戒烟，充足的维生素D状态和钙的摄入量;饮食机制还不太确定。在水果和蔬菜中发现的生物活性化合物类黄酮组的相关性研究较少。两项针对女性的人类流行病学研究发现，膳食总黄酮摄入量与骨密度呈正相关。黄酮类化合物可以通过上调促进成骨细胞功能的信号通路，通过减少氧化应激或慢性低度炎症的影响来防止骨丢失。在手稿中探讨了现有研究的局限性，并得出结论，在这个有前途的领域需要进一步的研究。
Osteoporosis and fragility fractures are a growing problem for our aging population with around 1 in 2 women and 1 in 5 men suffering from an osteoporotic fracture during their lifetime. Although there are established factors that can reduce the risk of fracture such as maintaining physical activity, ceasing smoking, and adequate vitamin D status, and intakes of calcium; dietary mechanisms are less well established. The relevance of the flavonoid group of bioactive compounds found in fruits and vegetables has been less investigated. Two human epidemiologic studies in women found positive associations between total dietary flavonoid intake and bone mineral density. Flavonoids may protect against bone loss by upregulating signaling pathways that promote osteoblast function, by reducing the effects of oxidative stress or chronic low-grade inflammation. The limitations of the existing research are explored in the manuscript and it is concluded that further research is needed, in this promising area.