Coffee and Tea Consumption in Relation to Risk of Rheumatoid Arthritis in the Women's Health Initiative Observational Cohort.
Coffee and Tea Consumption in Relation to Risk of Rheumatoid Arthritis in the Women's Health Initiative Observational Cohort.
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DOI：
10.1097/rhu.0000000000000788
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发表时间：
2019-04
期刊：
影响因子：
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通讯作者：
Howard BV
中科院分区：
文献类型：
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作者：
Lamichhane D;Collins C;Constantinescu F;Walitt B;Pettinger M;Parks C;Howard BV
通过妇女健康倡议观察性研究(WHI-OS)评估喝茶或喝咖啡是否与老年类风湿性关节炎(RA)风险增加有关。WHI-OS是一项从1993年到1998年进行的纵向前瞻性队列研究。76,853名女性完成了一份关于她们每天喝茶和喝咖啡的自填式问卷。经过三年的观察，观察到185例自报和确认的类风湿性关节炎病例。采用多变量COX比例风险模型分析消费习惯与疾病发病率的关系。趋势检验是使用分类变量来计算的，这些变量被建模为连续变量而不会崩溃。在那些喝咖啡的参与者中，与不喝咖啡的参与者相比，RA事件的风险比(HR)没有增加。咖啡的消耗量和制备方法(含咖啡因/不含咖啡因；过滤/不过滤)也不会改变类风湿性关节炎事件的风险。在趋势检验中，类风湿性关节炎的发生率与咖啡因茶的消费量呈正相关(p=0.03)。当评估饮用含咖啡因茶与不喝茶时，RA的发生率为1.40(CI为1.01-1.93，p=0.04)。在一大群老年女性的前瞻性队列中，饮用咖啡与类风湿关节炎事件之间没有关联。每天饮用含咖啡因的非草药茶与类风湿性关节炎事件之间存在少量关联。
To evaluate whether tea or coffee consumption is associated with an increased risk of older-onset rheumatoid arthritis (RA) using the Women’s Health Initiative Observational Study (WHI-OS). WHI-OS is a longitudinal prospective cohort study conducted from 1993 to 1998. 76,853 women completed a self-administered questionnaire about their daily consumption of tea and coffee. 185 self-reported and validated incident cases of RA were observed after three years of observation. Multivariable Cox proportional hazard models were performed to assess the relationship between consumption habits and disease incidence. Trend tests were calculated using categorical variables modeled as a continuous variable without collapsing. There was no increase in the hazard ratio (HR) for incident RA in those participants who drank coffee compared to those who did not. The amount of coffee consumed and the method of preparation (caffeinated/decaffeinated; filtered/unfiltered) also did not alter the risk of incident RA. There was a positive association of incident RA and caffeinated tea consumption in the trend test (p=0.03). When assessing any caffeinated tea consumption versus no tea consumption, the HR for incident RA was 1.40 (CI 1.01–1.93, p=0.04). In a large prospective cohort of older women, there was no association between coffee consumption and incident RA. A small association between daily caffeinated, non-herbal tea consumption and incident RA was found.