Menstrual cycle modulation of the relationship between cortisol and long-term memory
Menstrual cycle modulation of the relationship between cortisol and long-term memory
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DOI：
10.1016/j.psyneuen.2008.03.009
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发表时间：
2008-07-01
影响因子：
3.7
通讯作者：
Cahill, Larry
中科院分区：
文献类型：
--
作者：
Andreano, Joseph M.;Arjomandi, Hamidreza;Cahill, Larry
以前已经确定了卵巢激素在月经周期中波动的许多认知影响。然而，卵巢激素对压力条件下学习的影响还不清楚。在这个实验中，唾液皮质醇和回忆性能之间的关系进行了评估，在月经周期的不同阶段的妇女在编码后，皮质醇水平升高，使用冷压力（CPS）程序。对照组和CPS组在三个月经位置中的任何一个都没有发现记忆差异，也没有检测到压力条件和月经期之间的任何相互作用。然而，皮质醇与记忆的相关性在不同阶段存在显着差异。正相关的唾液皮质醇水平和回忆1周后的训练时，编码发生在中期黄体期，而没有显着的关系，发现在早期或晚期卵泡期。此外，皮质醇水平被发现在黄体中期升高。这些发现表明，糖皮质激素对记忆的影响是由性激素水平调节的。(c)2008爱思唯尔有限公司保留所有权利。
Numerous cognitive effects of fluctuations in ovarian hormones across the menstrual cycle have been previously identified. However, the influence of ovarian hormones on learning under stressful conditions is not well understood. In this experiment, the relationship between salivary cortisol and recall performance was assessed in women at hormonally distinct phases of the menstrual cycle at encoding after cortisol levels were elevated using a cold-presser stress (CPS) procedure. No memory difference was found between control and CPS groups in any of the three menstrual positions tested, nor was any interaction between stress condition and menstrual phase detected. However, significantly different correlations between cortisol and memory were found in the different phases. A positive correlation was found between salivary cortisol levels and recall 1 week post training when encoding occurred during the mid-luteal phase, whereas no significant relationship was found in either the early or the late follicular phase. In addition, cortisol levels were found to be elevated during the mid-luteal phase. These findings suggest that glucocorticoid effects on memory are modulated by sex hormone levels. (c) 2008 Elsevier Ltd. All rights reserved.