The changing pattern of common respiratory and enteric viruses among outpatient children in Shanghai, China: Two years of the COVID-19 pandemic
The changing pattern of common respiratory and enteric viruses among outpatient children in Shanghai, China: Two years of the COVID-19 pandemic
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DOI：
10.1002/jmv.27896
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发表时间：
2022-06-08
影响因子：
12.7
通讯作者：
Xu, Jin
中科院分区：
文献类型：
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作者：
Liu, Pengcheng;Xu, Menghua;Xu, Jin
为抗击2019冠状病毒病（COVID-19）大流行而采取的非药物干预措施（NPI）不仅减少了严重急性呼吸系统综合征冠状病毒2的传播，还对其他常见病毒的流行产生了影响。本研究旨在调查NPI对中国上海儿童常见呼吸道和肠道病毒的长期影响，因为NPI在2020年6月后放松。对COVID-19后（2020年6月至2022年1月）和COVID-19前（2018年6月至2020年1月）门诊急性呼吸道感染（阿尔蒂）和急性胃肠炎（AGE）患儿的实验室检查结果和临床资料进行分析和比较。2018年6月至2022年1月，共入组107 453例患者，其中阿尔蒂患者43 190例，AGE患者64 263例。大多数病毒的阳性率在COVID-19后时期有所下降，其中甲型流感病毒（-0.94%）下降最大，其次是腺病毒（AdV）（-61.54%），轮状病毒（-48.17%）和流感B（-40%）。然而，在COVID-19后时期，随着NPI的放松，呼吸道合胞病毒（RSV）和肠道AdV的阳性率有所增加。除此之外，于二零二一年夏季，观察到RSV活动出乎意料地反季节复苏，且复苏在5岁以上儿童中更为突出。目前放宽的非营利机构在控制常见呼吸道和肠道病毒方面的有效性各不相同。放松NPI可能会导致常见病毒的死灰复燃。
Nonpharmaceutical interventions (NPIs) taken to combat the coronavirus disease 2019 (COVID-19) pandemic have not only decreased the spread of severe acute respiratory syndrome coronavirus 2 but also have had an impact on the prevalence of other common viruses. This study aimed to investigate the long-term impact of NPIs on common respiratory and enteric viruses among children in Shanghai, China, as NPIs were relaxed after June 2020. The laboratory results and clinical data of outpatient children with acute respiratory tract infections (ARTI) and acute gastroenteritis (AGE) were analyzed and compared between the post-COVID-19 period (from June 2020 to January 2022) and pre-COVID-19 period (from June 2018 to January 2020). A total of 107 453 patients were enrolled from June 2018 to January 2022, including 43 190 patients with ARTI and 64 263 patients with AGE. The positive rates of most viruses decreased during the post-COVID-19 period, with the greatest decrease for influenza A (-0.94%), followed by adenoviruses (AdV) (-61.54%), rotaviruses (-48.17%), and influenza B (-40%). However, the positive rates of respiratory syncytial virus (RSV) and enteric AdV increased during the post-COVID-19 period as the NPIs were relaxed. Besides this, in the summer of 2021, an unexpected out-of-season resurgence of RSV activity was observed, and the resurgence was more prominent among children older than 5 years. The effectiveness of the current relaxed NPIs in control of common respiratory and enteric viruses was variable. Relaxation of NPIs might lead to the resurgence of common viruses.