SPECT Imaging for Radioaerosol Deposition and Clearance Studies.
SPECT Imaging for Radioaerosol Deposition and Clearance Studies.
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用于放射性气溶胶沉积和清除研究的 SPECT 成像。
DOI：
10.1089/jam.2006.19.8
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
E. Daviskas
中科院分区：
文献类型：
--
作者：
S. Eberl;H. Chan;E. Daviskas
平面伽马相机闪烁照相技术被广泛应用于测量放射性气溶胶的沉积和清除。单光子发射计算机断层扫描(SPECT)提供了放射性分布的三维(3D)重建，从而避免了将3D数据压缩成二维(2D)图像，并有可能提供对气溶胶沉积模式的更好评估。然而，SPECT传统上与较长的成像时间有关，这使得它不适合测量快速清除的放射性气溶胶的沉积和清除。多探测器SPECT系统可以在<；1分钟内收集完整的SPECT研究结果，允许动态SPECT评估初始沉积和随时间推移的清除情况。与外部源同时传输测量为绝对活动性量化提供衰减校正，并有助于定义感兴趣的肺体积。开发了一种动态SPECT成像协议，允许使用具有有限轴向视场的伽马相机从口咽到腹部进行快速成像。这不仅可以量化肺部的活动，也可以量化胸腔外的区域的活动。然而，快速动态SPECT成像在技术和计算上要求更高，并提供了较小的空间来减少受试者的放射性。已有研究表明，与平面成像相比，动态SPECT在检测渗透指数(PI)所测量的沉积变化方面更敏感。因此，SPECT可以更好地区分大小呼吸道，这对肺区域分析很重要。
Planar gamma camera scintigraphy is well established for measuring the deposition and clearance of radioaerosols. Single photon emission computed tomography (SPECT) provides threedimensional (3D) reconstructions of the radioactivity distribution, thus avoiding the compression of 3D data into two-dimensional (2D) images and potentially offering superior assessment of aerosol deposition patterns. However, SPECT has traditionally been associated with long imaging times, making it unsuitable for measuring deposition and clearance of radioaerosols with fast clearance. Multi-detector SPECT systems can collect complete SPECT studies in <1 min, allowing both initial deposition and clearance over time to be assessed by dynamic SPECT. Simultaneous transmission measurement with an external source provides attenuation correction for absolute activity quantification as well as aiding in the definition of the lung volume of interest. A dynamic SPECT imaging protocol has been developed to allow fast imaging from the oropharynx to the abdomen using gamma cameras with limited axial field of views. This allows activity quantification not only in the lungs, but also in areas outside the thorax. However, fast dynamic SPECT imaging is technically and computationally more demanding and provides less scope for reducing the radioactivity administered to the subjects. It has been shown that dynamic SPECT, compared to planar imaging, is more sensitive in detecting changes in deposition as measured by the Penetration Index (PI). Thus, SPECT can better differentiate between large and small airways, which is important for lung regional analysis.
影响因子：
3.1
作者：
M. Kassiou;S. Eberl;S. Meikle;A. Birrell;C. Constable;M. Fulham;D. Wong;J. Musachio
通讯作者：
M. Kassiou;S. Eberl;S. Meikle;A. Birrell;C. Constable;M. Fulham;D. Wong;J. Musachio
SPECT 采集过程中差异示踪剂冲洗的影响。
DOI：
--
发表时间：
1991
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Links,JM;Frank,TL;Becker,LC
通讯作者：
Becker,LC