The neuropeptide F/nitric oxide pathway is essential for shaping locomotor plasticity underlying locust phase transition
The neuropeptide F/nitric oxide pathway is essential for shaping locomotor plasticity underlying locust phase transition
复制标题
神经肽 F/一氧化氮途径对于塑造蝗虫相变的运动可塑性至关重要
DOI：
10.7554/elife.22526
复制
发表时间：
2017-03-27
期刊：
影响因子：
7.7
通讯作者：
Kang, Le
中科院分区：
文献类型：
--
作者：
Hou, Li;Yang, Pengcheng;Kang, Le
行为可塑性在群居动物中广泛存在，但对其潜在的神经和分子机制知之甚少。在这里，我们报道了神经肽F (NPF)/一氧化氮（NO）通路在成群迁徙蝗虫的运动可塑性中起关键作用。编码NPF1a和NPF2两种相关神经肽的转录本在拥挤期间水平降低，而NPF1a和NPF2受体的转录本水平在蝗虫隔离期间显著升高。NPF1a和NPF2对相相关运动活动均有抑制作用。一氧化氮合酶（NOS）是这两种NPFs的关键下游介质，它通过控制蝗虫大脑中NO的合成来调节相相关的运动活动。在机制上，NPF1a和NPF2分别通过抑制其磷酸化和降低其转录水平来修饰NOS活性，这些作用是由各自的受体介导的。我们的研究结果揭示了蝗群行为可塑性背后的层次神经化学机制，并为NPF/NO轴提供了见解。DOI: http://dx.doi.org/10.7554/eLife.22526.001
Behavioral plasticity is widespread in swarming animals, but little is known about its underlying neural and molecular mechanisms. Here, we report that a neuropeptide F (NPF)/nitric oxide (NO) pathway plays a critical role in the locomotor plasticity of swarming migratory locusts. The transcripts encoding two related neuropeptides, NPF1a and NPF2, show reduced levels during crowding, and the transcript levels of NPF1a and NPF2 receptors significantly increase during locust isolation. Both NPF1a and NPF2 have suppressive effects on phase-related locomotor activity. A key downstream mediator for both NPFs is nitric oxide synthase (NOS), which regulates phase-related locomotor activity by controlling NO synthesis in the locust brain. Mechanistically, NPF1a and NPF2 modify NOS activity by separately suppressing its phosphorylation and by lowering its transcript level, effects that are mediated by their respective receptors. Our results uncover a hierarchical neurochemical mechanism underlying behavioral plasticity in the swarming locust and provide insights into the NPF/NO axis. DOI: http://dx.doi.org/10.7554/eLife.22526.001