Enantioselective Nickel-Catalyzed Michael Additions of Azaarylacetates and Acetamides to Nitroalkenes
Enantioselective Nickel-Catalyzed Michael Additions of Azaarylacetates and Acetamides to Nitroalkenes
复制标题
DOI：
10.1002/chem.201202093
复制
发表时间：
2012-09-01
影响因子：
4.3
通讯作者：
Hon Wai Lam
中科院分区：
文献类型：
--
作者：
Fallan, Charlene;Hon Wai Lam
将镍放入其中：在催化不对称合成中作为底物被忽视的氮杂芳基乙酸酯和乙酰胺，在手性镍 (II)-双（二胺）络合物存在下，会与硝基烯烃发生高度对映选择性的迈克尔加成（参见方案；Bn= 苄基，MS= 分子筛）。该过程能够耐受亲核试剂中的多种氮杂芳烃。
Put a nickel in it: Azaarylacetates and acetamides, which have been neglected as substrates in catalytic asymmetric synthesis, undergo highly enantioselective Michael additions to nitroalkenes in the presence of a chiral nickel (II)-bis (diamine) complex (see scheme; Bn= benzyl, MS= molecular sieves). This process is tolerant of a wide variety of azaarenes in the pronucleophile.